STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdaRSeems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization (385 aa)    
Predicted Functional Partners:
garD
Catalyzes the dehydration of galactarate to form 5-dehydro-4- deoxy-D-glucarate
 
 
 0.824
garK
Belongs to the glycerate kinase type-1 family.
  
 0.742
fucR
Transcriptional activator of the fuc operon
      
 0.595
sfsA
Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism
      
 0.560
glxK
Belongs to the glycerate kinase type-1 family.
  
 0.544
yfbS
Uncharacterized transporter YfbS; Putative transport protein
     
 0.527
degP
DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures . Degrades transiently denatured and unfolded or misfolded proteins which accumulate in the periplasm following heat shock or other stress conditions . DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids . Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins . Its proteolytic activity is essential for the survi [...]
       0.508
hcaR
Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism
   
  
 0.498
yacH
Uncharacterized protein YacH; Putative membrane protein
  
   
 0.483
dgt
dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs
     
 0.450
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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