node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | deoD | b0469 | b4384 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | 0.943 |
apt | gmk | b0469 | b3648 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | 0.943 |
apt | gpt | b0469 | b0238 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Xanthine-guanine phsophoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine | 0.972 |
apt | gsk | b0469 | b0477 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Inosine/guanosine kinase; Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion | 0.930 |
apt | guaA | b0469 | b2507 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Gmp synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP | 0.994 |
apt | guaB | b0469 | b2508 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.810 |
apt | guaC | b0469 | b0104 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Gmp reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides | 0.966 |
apt | hpt | b0469 | b0125 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine | 0.969 |
apt | yaiE | b0469 | b0391 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Purine/pyrimidine-nucleoside phosphorylase; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. Is not able to produce D-ribose 1-phosphate from D-ribose and phosphate | 0.972 |
deoD | apt | b4384 | b0469 | Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | 0.943 |
deoD | gpt | b4384 | b0238 | Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | Xanthine-guanine phsophoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine | 0.964 |
deoD | gsk | b4384 | b0477 | Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | Inosine/guanosine kinase; Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion | 0.954 |
deoD | guaA | b4384 | b2507 | Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | Gmp synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP | 0.672 |
deoD | guaB | b4384 | b2508 | Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.565 |
deoD | guaC | b4384 | b0104 | Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | Gmp reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides | 0.462 |
deoD | hpt | b4384 | b0125 | Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine | 0.945 |
deoD | xapA | b4384 | b2407 | Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | Purine nucleoside phosphorylase 2; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. This protein can degrade all purine nucleosides including xanthosine, inosine and guanosine, but cannot cleave adenosine, deoxyadenosine or hypoxanthine arabinoside. Has a preference for the neutral over the monoanionic form of xanthosine | 0.942 |
deoD | yaiE | b4384 | b0391 | Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules | Purine/pyrimidine-nucleoside phosphorylase; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. Is not able to produce D-ribose 1-phosphate from D-ribose and phosphate | 0.903 |
gmk | apt | b3648 | b0469 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | 0.943 |
gmk | gpt | b3648 | b0238 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | Xanthine-guanine phsophoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine | 0.917 |