STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
frsAFermentation-respiration switch protein; Displays esterase activity toward pNP-butyrate (414 aa)    
Predicted Functional Partners:
yihX
alpha-D-glucose-1-phosphate phosphatase, anomer-specific; Catalyzes the dephosphorylation of alpha-D-glucose 1- phosphate (Glc1P) and, to a lesser extent, of other sugar phosphates . Has no activity with the beta form of Glc1P. In addition, YihX has significant phosphatase activity against pyridoxal phosphate (PLP) and low beta-phosphoglucomutase activity
  
 
 0.907
yagA
Uncharacterized protein YagA; Pseudogene, CP4-6 prophage;Phage or Prophage Related
      
 0.900
crr
Glucose-specific enzyme iia component of pts; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane . The enzyme II complex composed of PtsG and Crr is involved in glucose transport . The non-phosphorylated EIII-Glc is an inhibitor for uptake of certain sugars such as maltose, melibiose, lactose, and glycerol. Phosphorylated EIII-Glc, however, may be an activator for adenylate cyclase. It is an [...]
    
 
 0.878
yijD
annotation not available
  
     0.768
cyaA
Adenylate cyclase, class 1; Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp-cAMP, which then induces its own transcription again
  
   
 0.765
dkgB
2,5-diketo-D-gluconate reductase B; Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG)
  
  
 0.737
ytfK
annotation not available
  
     0.717
yaeH
DUF3461 domain-containing protein YaeH; Belongs to the UPF0325 family
  
     0.714
mlc
Glucosamine anaerobic growth regulon transcriptional repressor; Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT
  
   
 0.699
ybjD
annotation not available
  
     0.685
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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