STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yafYCP4-6 prophage; inner membrane lipoprotein YafY; When overproduced strongly induces degP through the activation of the two-component envelope stress response system CpxA/CpxR (147 aa)    
Predicted Functional Partners:
ykfB
Uncharacterized protein YkfB; Phage or Prophage Related; To E.coli YfjT
  
    0.825
nlpE
Lipoprotein involved with copper homeostasis and adhesion; Involved in copper homeostasis, could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes . Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation . Functions during envelope stress responses; when overproduced induces degP through the activation of the two-component envelope stress response system CpxA/CpxR DegP induction seems to require membrane anchoring of this protein . Structural changes and/or interaction of the CXXC [...]
      
 0.708
ykfF
UPF0401 protein YkfF; Phage or Prophage Related; Belongs to the UPF0401 family
  
    0.618
ybjX
DUF535 domain-containing protein YbjX; To H.influenzae HI_0461
   
    0.437
yafX
Uncharacterized protein YafX; Phage or Prophage Related; Belongs to the antirestriction protein family
  
    0.425
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.