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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
paoAXanthine dehydrogenase yagt iron-sulfur-binding subunit; Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes. It might play a role in the detoxification of aldehydes to avoid cell damage (229 aa)    
Predicted Functional Partners:
paoC
Putative xanthine dehydrogenase YagR molybdenum-binding subunit; Enzyme; Not classified; Belongs to the xanthine dehydrogenase family
 0.999
paoB
Paoabc aldehyde oxidoreductase, fad-containing subunit; Putative xanthine dehydrogenase YagS FAD-binding subunit; Enzyme; Not classified
 
 0.999
xdhB
Putative xanthine dehydrogenase fad-binding subunit xdhb; Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism)
  
 0.998
paoD
Chaperone required for the production of an active PaoABC aldehyde oxidoreductase. Stabilizes the PaoC subunit and is required for the insertion of the molybdenum cofactor into this subunit . Binds molybdenum cofactor. Binds the molybdopterin cytosine dinucleotide (MCD) form of the cofactor after its formation by the molybdenum cofactor cytidylyltransferase MocA
 
  
 0.997
xdhA
Putative xanthine dehydrogenase molybdenum-binding subunit xdha; Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism). Deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage
 
 0.996
xdhD
Fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit and fe-s binding subunit; Probably has no xanthine dehydrogenase activity; however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage
 
 
 0.969
adeD
Cryptic adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
    
  0.904
rihB
Pyrimidine-specific ribonucleoside hydrolase rihb; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. Has a low but significant activity for the purine nucleoside xanthosine
   
 
  0.901
guaD
Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia
    
  0.901
hpt
Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine
     
  0.900
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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