node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hypT | nemR | b4327 | b1649 | Hypochlorite-responsive transcription factor; Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur-regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study. Belongs to the LysR transcriptional regulatory family. | Transcriptional repressor for the nemRA-gloA operon, quinone-, glyoxal-, and HOCl-activated; Involved in response to both electrophiles and reactive chlorine species (RCS). Represses the transcription of the nemRA-gloA operon by binding to the NemR box. May sense electrophiles, primarily quinones and glyoxals, as redox signals and regulate the redox state by modulating the expression of nemA and gloA. Also uses the oxidation status of HOCl-sensitive cysteine residues to respond to bleach and related RCS. Involved in response to methylglyoxal. | 0.901 |
hypT | rclR | b4327 | b0305 | Hypochlorite-responsive transcription factor; Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur-regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study. Belongs to the LysR transcriptional regulatory family. | Reactive chlorine species (RCS)-specific activator of the rcl genes; Involved in reactive chlorine species (RCS) stress resistance. Upregulates, in response to hypochlorous acid (HOCl), the expression of three genes essential for survival of RCS stress (rclA, rclB and rclC) and its own expression. | 0.922 |
hypT | ydiP | b4327 | b1696 | Hypochlorite-responsive transcription factor; Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur-regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study. Belongs to the LysR transcriptional regulatory family. | Putative ARAC-type regulatory protein; Protein involved in transcription and regulation of transcription, DNA-dependent. | 0.450 |
marA | melR | b1531 | b4118 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | 0.730 |
marA | rclR | b1531 | b0305 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Reactive chlorine species (RCS)-specific activator of the rcl genes; Involved in reactive chlorine species (RCS) stress resistance. Upregulates, in response to hypochlorous acid (HOCl), the expression of three genes essential for survival of RCS stress (rclA, rclB and rclC) and its own expression. | 0.734 |
marA | ydiP | b1531 | b1696 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Putative ARAC-type regulatory protein; Protein involved in transcription and regulation of transcription, DNA-dependent. | 0.748 |
marA | yidL | b1531 | b3680 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.720 |
melR | marA | b4118 | b1531 | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | 0.730 |
melR | rclR | b4118 | b0305 | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | Reactive chlorine species (RCS)-specific activator of the rcl genes; Involved in reactive chlorine species (RCS) stress resistance. Upregulates, in response to hypochlorous acid (HOCl), the expression of three genes essential for survival of RCS stress (rclA, rclB and rclC) and its own expression. | 0.751 |
melR | soxS | b4118 | b4062 | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | Superoxide response regulon transcriptional activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. | 0.710 |
melR | ydiP | b4118 | b1696 | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | Putative ARAC-type regulatory protein; Protein involved in transcription and regulation of transcription, DNA-dependent. | 0.678 |
melR | yidL | b4118 | b3680 | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.666 |
nemR | hypT | b1649 | b4327 | Transcriptional repressor for the nemRA-gloA operon, quinone-, glyoxal-, and HOCl-activated; Involved in response to both electrophiles and reactive chlorine species (RCS). Represses the transcription of the nemRA-gloA operon by binding to the NemR box. May sense electrophiles, primarily quinones and glyoxals, as redox signals and regulate the redox state by modulating the expression of nemA and gloA. Also uses the oxidation status of HOCl-sensitive cysteine residues to respond to bleach and related RCS. Involved in response to methylglyoxal. | Hypochlorite-responsive transcription factor; Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur-regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study. Belongs to the LysR transcriptional regulatory family. | 0.901 |
nemR | rclR | b1649 | b0305 | Transcriptional repressor for the nemRA-gloA operon, quinone-, glyoxal-, and HOCl-activated; Involved in response to both electrophiles and reactive chlorine species (RCS). Represses the transcription of the nemRA-gloA operon by binding to the NemR box. May sense electrophiles, primarily quinones and glyoxals, as redox signals and regulate the redox state by modulating the expression of nemA and gloA. Also uses the oxidation status of HOCl-sensitive cysteine residues to respond to bleach and related RCS. Involved in response to methylglyoxal. | Reactive chlorine species (RCS)-specific activator of the rcl genes; Involved in reactive chlorine species (RCS) stress resistance. Upregulates, in response to hypochlorous acid (HOCl), the expression of three genes essential for survival of RCS stress (rclA, rclB and rclC) and its own expression. | 0.893 |
rclA | rclB | b0304 | b0303 | Reactive chlorine stress species (RCS) resistance protein; Probably involved in reactive chlorine species (RCS) stress resistance. | Reactive chlorine species (RCS) stress resistance periplasmic protein; Probably involved in reactive chlorine species (RCS) stress resistance; Belongs to the BhsA/McbA family. | 0.906 |
rclA | rclC | b0304 | b0301 | Reactive chlorine stress species (RCS) resistance protein; Probably involved in reactive chlorine species (RCS) stress resistance. | Inner membrane protein RclC; Probably involved in reactive chlorine species (RCS) stress resistance. | 0.963 |
rclA | rclR | b0304 | b0305 | Reactive chlorine stress species (RCS) resistance protein; Probably involved in reactive chlorine species (RCS) stress resistance. | Reactive chlorine species (RCS)-specific activator of the rcl genes; Involved in reactive chlorine species (RCS) stress resistance. Upregulates, in response to hypochlorous acid (HOCl), the expression of three genes essential for survival of RCS stress (rclA, rclB and rclC) and its own expression. | 0.902 |
rclB | rclA | b0303 | b0304 | Reactive chlorine species (RCS) stress resistance periplasmic protein; Probably involved in reactive chlorine species (RCS) stress resistance; Belongs to the BhsA/McbA family. | Reactive chlorine stress species (RCS) resistance protein; Probably involved in reactive chlorine species (RCS) stress resistance. | 0.906 |
rclB | rclC | b0303 | b0301 | Reactive chlorine species (RCS) stress resistance periplasmic protein; Probably involved in reactive chlorine species (RCS) stress resistance; Belongs to the BhsA/McbA family. | Inner membrane protein RclC; Probably involved in reactive chlorine species (RCS) stress resistance. | 0.982 |
rclB | rclR | b0303 | b0305 | Reactive chlorine species (RCS) stress resistance periplasmic protein; Probably involved in reactive chlorine species (RCS) stress resistance; Belongs to the BhsA/McbA family. | Reactive chlorine species (RCS)-specific activator of the rcl genes; Involved in reactive chlorine species (RCS) stress resistance. Upregulates, in response to hypochlorous acid (HOCl), the expression of three genes essential for survival of RCS stress (rclA, rclB and rclC) and its own expression. | 0.882 |