STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
codBCytosine permease; Required for cytosine transport into the cell (419 aa)    
Predicted Functional Partners:
codA
Cytosine deaminase; Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5- fluorocytosine (5FC) to 5-fluorouracil (5FU); this activity allows the formation of a cytotoxic chemotherapeutic agent from a non- cytotoxic precursor; Belongs to the metallo-dependent hydrolases superfamily. [...]
 
  
 0.997
uraA
Uracil permease; Transport of uracil in the cell
  
  
 0.880
pyrB
Aspartate carbamoyltransferase catalytic subunit; Enzyme; Pyrimidine ribonucleotide biosynthesis; Belongs to the ATCase/OTCase family
  
  
 0.804
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily
   
  
 0.789
pyrI
Aspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase; Belongs to the PyrI family
   
    0.733
xanP
Xanthine permease XanP; Specific, proton motive force-dependent high-affinity transporter for xanthine; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily
  
  
 0.707
carA
Carbamoyl-phosphate synthase small chain; Protein involved in arginine biosynthetic process and pyrimidine nucleotide biosynthetic process
   
    0.698
yfeS
annotation not available
      
 0.689
yfeK
annotation not available
      
 0.680
carB
Carbamoyl-phosphate synthase large chain; Protein involved in arginine biosynthetic process and pyrimidine nucleotide biosynthetic process; Belongs to the CarB family
   
  
 0.675
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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