STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cynRLysr family transcriptional regulator, cyn operon transcriptional activator; Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region (299 aa)    
Predicted Functional Partners:
cynT
Carbonic anhydrase 1; Reversible hydration of carbon dioxide. Carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (CynS) diffuses out of the cell faster than it would be hydrated to bicarbonate, so the apparent function of this enzyme is to catalyze the hydration of carbon dioxide and thus prevent depletion of cellular bicarbonate
 
  
 0.957
cynS
Cyanate aminohydrolase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
 
   
 0.910
cynX
Mfs transporter, cp family, cyanate transporter; This protein is part of an active transport system that transports exogenous cyanate into E.coli cells
 
   
 0.896
betI
Tetr/acrr family transcriptional regulator, transcriptional repressor of bet genes; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine
  
   
 0.769
yqjI
Padr family putative transcriptional regulator; Represses the expression of YqjH which is involved in iron homeostasis under excess nickel conditions. Also represses its own expression
      
 0.731
yiaU
Putative lysr-type dna-binding transcriptional regulator yiau; Belongs to the LysR transcriptional regulatory family
  
   
 0.724
mhpR
Iclr family transcriptional regulator, mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway
      
 0.615
rayT
Rayt rep element-mobilizing transposase; Transposase that is always flanked by repeated extragenic palindrome (REP) sequences, which are clustered in structures called bacterial interspersed mosaic elements (BIMEs). RayT catalyzes cleavage and recombination of BIMEs. Binds REP sequences and cleaves BIMEs both upstream and downstream of the REP sequence. Could be important in the creation of BIME variability and amplification
      
 0.608
ybeF
Putative lysr-type dna-binding transcriptional regulator ybef; Belongs to the LysR transcriptional regulatory family
  
   
 0.570
feaR
Arac family transcriptional regulator, positive regulator of tyna and feab; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism
  
  
 0.553
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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