STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lacYLactose permease; Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Can transport lactose, melibiose, lactulose or the analog methyl-1-thio-beta,D- galactopyranoside (TMG), but not sucrose or fructose. The substrate specificity is directed toward the galactopyranosyl moiety of the substrate. (417 aa)    
Predicted Functional Partners:
lacA
Thiogalactoside acetyltransferase; Catalyzes the CoA-dependent transfer of an acetyl group to the 6-O-methyl position of a range of galactosides, glucosides, and lactosides. May assist cellular detoxification by acetylating non-metabolizable pyranosides, thereby preventing their reentry into the cell (Probable). Belongs to the transferase hexapeptide repeat family.
  
  
 0.997
lacZ
beta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family.
 
  
 0.996
lacI
Lactose-inducible lac operon transcriptional repressor; Repressor of the lactose operon. Binds allolactose as an inducer.
 
   
 0.945
glpT
Sn-glycerol-3-phosphate transporter; Responsible for glycerol-3-phosphate uptake.
   
  
 0.937
fucP
L-fucose transporter; Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose.
      
 0.927
melB
Melibiose:sodium symporter; Responsible for melibiose and other galactoside transport. It is capable of using hydrogen, sodium, and lithium cations as coupling cations for cotransport, depending on the particular sugar transported (symport system).
  
  
 0.916
xylE
D-xylose transporter; Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Glucose is not transported, but can compete for xylose binding sites and can inhibit xylose transport (in vitro). Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
  
  
 0.910
pheP
Phenylalanine transporter; Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
    
 
 0.875
emrD
Multidrug efflux system protein; Multidrug resistance pump that participates in a low energy shock adaptive response; Belongs to the major facilitator superfamily.
      
 0.874
glpG
Rhomboid protease GlpG; Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
   
  
 0.811
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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