node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alkB | panE | b2212 | b0425 | Oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions; Dioxygenase that repairs alkylated DNA and RNA containing 3- methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha- ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not t [...] | 2-dehydropantoate reductase, NADPH-specific; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.662 |
coaA | coaD | b3974 | b3634 | Pantothenate kinase; Protein involved in coenzyme A biosynthetic process; Belongs to the prokaryotic pantothenate kinase family. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. CoA is not a substrate for the enzyme ; Belongs to the bacterial CoaD family. | 0.991 |
coaA | dfp | b3974 | b3639 | Pantothenate kinase; Protein involved in coenzyme A biosynthetic process; Belongs to the prokaryotic pantothenate kinase family. | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine. In the C-terminal section; belongs to the PPC synthetase family. | 0.990 |
coaA | panB | b3974 | b0134 | Pantothenate kinase; Protein involved in coenzyme A biosynthetic process; Belongs to the prokaryotic pantothenate kinase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate. | 0.658 |
coaA | panC | b3974 | b0133 | Pantothenate kinase; Protein involved in coenzyme A biosynthetic process; Belongs to the prokaryotic pantothenate kinase family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.978 |
coaA | panD | b3974 | b0131 | Pantothenate kinase; Protein involved in coenzyme A biosynthetic process; Belongs to the prokaryotic pantothenate kinase family. | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family. | 0.626 |
coaA | panE | b3974 | b0425 | Pantothenate kinase; Protein involved in coenzyme A biosynthetic process; Belongs to the prokaryotic pantothenate kinase family. | 2-dehydropantoate reductase, NADPH-specific; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.649 |
coaD | coaA | b3634 | b3974 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. CoA is not a substrate for the enzyme ; Belongs to the bacterial CoaD family. | Pantothenate kinase; Protein involved in coenzyme A biosynthetic process; Belongs to the prokaryotic pantothenate kinase family. | 0.991 |
coaD | dfp | b3634 | b3639 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. CoA is not a substrate for the enzyme ; Belongs to the bacterial CoaD family. | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine. In the C-terminal section; belongs to the PPC synthetase family. | 0.994 |
coaD | panB | b3634 | b0134 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. CoA is not a substrate for the enzyme ; Belongs to the bacterial CoaD family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate. | 0.647 |
coaD | panC | b3634 | b0133 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. CoA is not a substrate for the enzyme ; Belongs to the bacterial CoaD family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.672 |
coaD | panD | b3634 | b0131 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. CoA is not a substrate for the enzyme ; Belongs to the bacterial CoaD family. | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family. | 0.611 |
coaD | panE | b3634 | b0425 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. CoA is not a substrate for the enzyme ; Belongs to the bacterial CoaD family. | 2-dehydropantoate reductase, NADPH-specific; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.617 |
dfp | coaA | b3639 | b3974 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine. In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase; Protein involved in coenzyme A biosynthetic process; Belongs to the prokaryotic pantothenate kinase family. | 0.990 |
dfp | coaD | b3639 | b3634 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine. In the C-terminal section; belongs to the PPC synthetase family. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. CoA is not a substrate for the enzyme ; Belongs to the bacterial CoaD family. | 0.994 |
dfp | panB | b3639 | b0134 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine. In the C-terminal section; belongs to the PPC synthetase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate. | 0.917 |
dfp | panC | b3639 | b0133 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine. In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.973 |
dfp | panD | b3639 | b0131 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine. In the C-terminal section; belongs to the PPC synthetase family. | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family. | 0.666 |
dfp | panE | b3639 | b0425 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine. In the C-terminal section; belongs to the PPC synthetase family. | 2-dehydropantoate reductase, NADPH-specific; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.842 |
ilvC | panB | b3774 | b0134 | Ketol-acid reductoisomerase, NAD(P)-binding; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. Also able to use 2-ketopantoate, 2-ketoisovalerate, 2-ketovalerate, 2-ketobutyrate [...] | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate. | 0.840 |