Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| acrS | mdlA | b3264 | b0448 | Tetr/acrr family transcriptional regulator, acref/envcd operon repressor; Potential regulator protein for the acrEF/envCD genes | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | 0.509 |
| acrS | uidC | b3264 | b1615 | Tetr/acrr family transcriptional regulator, acref/envcd operon repressor; Potential regulator protein for the acrEF/envCD genes | Putative outer membrane porin for beta-glucuronides porin protein; Enhances the activity of the UidB (GusB) glucuronide transporter, on its own however it has no transport activity. Glucuronide transport does not occur in strain K12 due to a variant at position 100 of the UidB (GusB, AC P0CE44, AC P0CE45) protein | 0.520 |
| amtB | glnK | b0451 | b0450 | Ammonium transporter, amt family; Involved in the uptake of ammonia | Nitrogen assimilation regulatory protein for glnl, glne, and amtb; P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity) | 0.999 |
| amtB | mdlA | b0451 | b0448 | Ammonium transporter, amt family; Involved in the uptake of ammonia | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | 0.528 |
| amtB | mdlB | b0451 | b0449 | Ammonium transporter, amt family; Involved in the uptake of ammonia | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | 0.526 |
| amtB | ybaO | b0451 | b0447 | Ammonium transporter, amt family; Involved in the uptake of ammonia | Putative dna-binding transcriptional regulator; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. No other DNA target was identified in strain K12 / BW25113. Thiosulfate does not activate its transcription function. Overexpression doubles hydrogen sulfide production in the presence of cysteine | 0.445 |
| cof | mdlA | b0446 | b0448 | Thiamine pyrimidine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). Can also hydrolyze other substrates such as MeO-HMP-PP and 4-amino-2-trifluoromethyl 5- hydroxymethylpyrimidine pyrophosphate (CF3-HMP-PP) to give MeO-HMP-P and 4-amino-2-trifluoromethyl-5-hydroxymethylpyrimidine phosphate. This hydrolysis generates resistance to the antibiotics (bacimethrin, CF3- HMP) by reducing the formation of their toxic forms, 2'-methoxythiamin pyrophosphate (M [...] | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | 0.457 |
| cof | mdlB | b0446 | b0449 | Thiamine pyrimidine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). Can also hydrolyze other substrates such as MeO-HMP-PP and 4-amino-2-trifluoromethyl 5- hydroxymethylpyrimidine pyrophosphate (CF3-HMP-PP) to give MeO-HMP-P and 4-amino-2-trifluoromethyl-5-hydroxymethylpyrimidine phosphate. This hydrolysis generates resistance to the antibiotics (bacimethrin, CF3- HMP) by reducing the formation of their toxic forms, 2'-methoxythiamin pyrophosphate (M [...] | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | 0.457 |
| cof | ybaO | b0446 | b0447 | Thiamine pyrimidine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). Can also hydrolyze other substrates such as MeO-HMP-PP and 4-amino-2-trifluoromethyl 5- hydroxymethylpyrimidine pyrophosphate (CF3-HMP-PP) to give MeO-HMP-P and 4-amino-2-trifluoromethyl-5-hydroxymethylpyrimidine phosphate. This hydrolysis generates resistance to the antibiotics (bacimethrin, CF3- HMP) by reducing the formation of their toxic forms, 2'-methoxythiamin pyrophosphate (M [...] | Putative dna-binding transcriptional regulator; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. No other DNA target was identified in strain K12 / BW25113. Thiosulfate does not activate its transcription function. Overexpression doubles hydrogen sulfide production in the presence of cysteine | 0.515 |
| entF | mdlA | b0586 | b0448 | Enterobactin synthase multienzyme complex component, atp-dependent; Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE) | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | 0.603 |
| entF | mdlB | b0586 | b0449 | Enterobactin synthase multienzyme complex component, atp-dependent; Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE) | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | 0.603 |
| glnK | amtB | b0450 | b0451 | Nitrogen assimilation regulatory protein for glnl, glne, and amtb; P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity) | Ammonium transporter, amt family; Involved in the uptake of ammonia | 0.999 |
| glnK | mdlA | b0450 | b0448 | Nitrogen assimilation regulatory protein for glnl, glne, and amtb; P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity) | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | 0.482 |
| glnK | mdlB | b0450 | b0449 | Nitrogen assimilation regulatory protein for glnl, glne, and amtb; P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity) | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | 0.482 |
| glnK | ybaO | b0450 | b0447 | Nitrogen assimilation regulatory protein for glnl, glne, and amtb; P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity) | Putative dna-binding transcriptional regulator; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. No other DNA target was identified in strain K12 / BW25113. Thiosulfate does not activate its transcription function. Overexpression doubles hydrogen sulfide production in the presence of cysteine | 0.433 |
| mdlA | acrS | b0448 | b3264 | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | Tetr/acrr family transcriptional regulator, acref/envcd operon repressor; Potential regulator protein for the acrEF/envCD genes | 0.509 |
| mdlA | amtB | b0448 | b0451 | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | Ammonium transporter, amt family; Involved in the uptake of ammonia | 0.528 |
| mdlA | cof | b0448 | b0446 | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | Thiamine pyrimidine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). Can also hydrolyze other substrates such as MeO-HMP-PP and 4-amino-2-trifluoromethyl 5- hydroxymethylpyrimidine pyrophosphate (CF3-HMP-PP) to give MeO-HMP-P and 4-amino-2-trifluoromethyl-5-hydroxymethylpyrimidine phosphate. This hydrolysis generates resistance to the antibiotics (bacimethrin, CF3- HMP) by reducing the formation of their toxic forms, 2'-methoxythiamin pyrophosphate (M [...] | 0.457 |
| mdlA | entF | b0448 | b0586 | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | Enterobactin synthase multienzyme complex component, atp-dependent; Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE) | 0.603 |
| mdlA | glnK | b0448 | b0450 | Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family | Nitrogen assimilation regulatory protein for glnl, glne, and amtb; P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity) | 0.482 |
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