STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdlBAtp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family (593 aa)    
Predicted Functional Partners:
mdlA
Atp-binding cassette, subfamily b, multidrug efflux pump; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family
 
 
0.984
ybaO
Putative dna-binding transcriptional regulator; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. No other DNA target was identified in strain K12 / BW25113. Thiosulfate does not activate its transcription function. Overexpression doubles hydrogen sulfide production in the presence of cysteine
 
  
 0.760
entF
Enterobactin synthase multienzyme complex component, atp-dependent; Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE)
  
  
 0.603
ykfA
CP4-6 prophage; putative GTP-binding protein YkfA; To E.coli YfjP and YeeP
      
 0.594
yagN
CP4-6 prophage; protein YagN; Uncharacterized protein YagN; Phage or Prophage Related
      
 0.579
acrF
Multidrug efflux pump rnd permease acrf; Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents
     
 0.534
emrD
Mfs transporter, dha1 family, 2-module integral membrane pump emrd; Multidrug resistance pump that participates in a low energy shock adaptive response
   
 
 0.533
amtB
Ammonium transporter, amt family; Involved in the uptake of ammonia
  
   0.526
yagG
Putative d-xylonate transporter yagg; Putative glycoside/cation symporter YagG; Putative permease
   
  
 0.509
mdtC
Multidrug efflux pump rnd permease subunit mdtc; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function
     
 0.509
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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