STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tomBProtein that modulates hha toxicity; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA (124 aa)    
Predicted Functional Partners:
hha
Haemolysin expression modulating protein; Down-regulates hemolysin (hly) expression in complex with H- NS . Stimulates transposition events in vivo . Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Binds DNA and influences DNA topology in response to environmental stimuli; does not however interact with DNA in the absence of H-NS . Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR . Decreases biofilm formation by [...]
 
  
 0.998
yefM
Yefm antitoxin of the yoeb-yefm toxin-antitoxin pair and dna binding transcriptional repressor; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of the YoeB toxin. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor
   
  
 0.746
rzpD
DLP12 prophage; putative prophage endopeptidase RzpD; Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the murein component of the bacterial cell wall (By similarity)
      
 0.732
yoeB
Toxic component of a type II toxin-antitoxin (TA) system. Its mode of function is controversial; it has been proposed to be an mRNA interferase but also an inhibitor of translation initiation. When overproduced in wild-type cells, inhibits bacterial growth and translation by cleavage of mRNA molecules while it has a weak effect on colony forming ability. Overproduction of Lon protease specifically activates YoeB-dependent mRNA cleavage, leading to lethality. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor. Also shown in vit [...]
      
 0.732
yfjZ
CP4-57 prophage; putative antitoxin of the YpjF-YfjZ toxin-antitoxin system; Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of cognate toxin YpjF . Also counteracts the effect of non-cognate toxins CbtA and YfkI
      
 0.731
yacC
annotation not available
  
     0.726
ylaC
annotation not available
 
     0.720
maa
Maltose o-acetyltransferase; Catalyzes the CoA-dependent transfer of an acetyl group to maltose and other sugars . Acetylates glucose exclusively at the C6 position and maltose at the C6 position of the non-reducing end glucosyl moiety. Is able to acetylate maltooligosaccharides
  
  
 0.693
bssS
Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway
  
   
 0.687
ratB
Putative component of the rsx system; Does not function as an antitoxin to the upstream RatA toxin
      
 0.677
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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