STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ybaQPutative dna-binding transcriptional regulator ybaq; Belongs to the VapA/VapI family (113 aa)    
Predicted Functional Partners:
yeiE
Putative lysr-type transcriptional regulator yeie; Belongs to the LysR transcriptional regulatory family
      
 0.737
yfeC
Putative dna-binding transcriptional regulator yfec; To E.coli YfiI and P.aeruginosa RluD
      
 0.737
yfeD
annotation not available
      
 0.733
ybiH
Tetr/acrr family transcriptional regulator, regulator of cefoperazone and chloramphenicol sensitivity; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons
      
 0.731
higB
Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics; overexpression of this protein induces persisters resistant to ciprofloxacin and ampicillin
 
   
 0.699
yieP
annotation not available
      
 0.682
ydaT
Rac prophage; protein ydat; Uncharacterized protein YdaT; Phage or Prophage Related
      
 0.607
ydaS
Rac prophage; toxin ydas; Uncharacterized protein YdaS; Phage or Prophage Related
      
 0.604
prlF
Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the YhaV toxin and neutralizes its ribonuclease activity. Also acts as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
  
   
 0.593
ybaP
Trab family protein ybap; Uncharacterized protein YbaP; Putative ligase
       0.577
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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