STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
qmcAPhb domain membrane-anchored putative protease; Identified as a multi-copy suppressor of an FtsH/HtpX protease double disruption mutant. May play a role in the quality control of integral membrane proteins (305 aa)    
Predicted Functional Partners:
ybbJ
annotation not available
 
  
 0.996
ftsH
Atp-dependent zinc metalloprotease ftsh; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Degrades a few membrane proteins that have not been assembled into complexes such as SecY, F(0) ATPase subunit a and YccA, and also cytoplasmic proteins sigma-32, LpxC, KdtA and phage lambda cII protein among others. Degrades membrane proteins in a processive manner starting at either the N- or C-terminus; recognition requires a cytoplasmic tail of about 20 residues with no appar [...]
   
 0.921
fetB
Putative iron abc exporter membrane subunit fetb; Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for the translocation of the substrate across the membrane
     
 0.879
fetA
Putative iron abc exporter atp-binding subunit feta; Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for energy coupling to the transport system
     
 0.866
yqiK
Phb family membrane protein, function unknown; Putative membrane protein
   
  
 0.844
htpX
Zinc dependent endoprotease; Membrane-localized protease able to endoproteolytically degrade overproduced SecY but not YccA, another membrane protein. It seems to cleave SecY at specific cytoplasmic sites. Does not require ATP. Its natural substrate has not been identified. Probably plays a role in the quality control of integral membrane proteins
  
 
 0.794
rlmN
Dual specificity 23s rrna m(2)a2503, trna m(2)a37 methyltransferase, sam-dependent; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity. Unmodified tRNA is not a suitable substrate for RlmN, which suggests that RlmN works in a late step during tRNA maturation
      0.734
ybbO
Uncharacterized oxidoreductase YbbO; Putative enzyme; Not classified; Belongs to the short-chain dehydrogenases/reductases (SDR) family
  
 
 0.617
yjjV
Tatd dnase family protein; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family
   
  
 0.608
yqhA
annotation not available
      
 0.601
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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