STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ybcOBased on its fold and a conserved His residue, has been predicted to be a nuclease (96 aa)    
Predicted Functional Partners:
rusA
Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
 
   
 0.990
ydfU
Uncharacterized protein YdfU; Phage or Prophage Related
   
 
 0.898
ninE
Prophage NinE homolog; Similar to phage 82 and lambda proteins
  
    0.853
ybcN
Uncharacterized protein YbcN; Phage or Prophage Related
       0.845
ylcG
Uncharacterized protein YlcG; Phage or Prophage Related; To equivalent protein in phage 82
       0.845
ylcH
Uncharacterized protein YlcH; Phage or Prophage Related
       0.845
quuD
Positively regulate expression of some phage genes. Bacterial host RNA polymerase modified by antitermination proteins transcribes through termination sites that otherwise prevent expression of the regulated genes (By similarity)
 
     0.656
yhhZ
Belongs to the hcp1 family
      
 0.606
recE
Is involved in the RecE pathway of recombination. Catalyzes the degradation of double-stranded DNA. Acts progressively in a 5' to 3' direction, releasing 5'-phosphomononucleotides. Has a strong preference for linear duplex substrate DNA and appears to be unable to initiate degradation from single-stranded breaks in DNA
  
    0.549
ybcM
Uncharacterized HTH-type transcriptional regulator YbcM; Putative ARAC-type regulatory protein
       0.548
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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