STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
rusADLP12 prophage; crossover junction endodeoxyribonuclease RusA; Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (120 aa)    
Predicted Functional Partners:
DLP12 prophage; putative nuclease YbcO; Based on its fold and a conserved His residue, has been predicted to be a nuclease
Qin prophage; protein ydfu; Uncharacterized protein YdfU; Phage or Prophage Related
DLP12 prophage; NinE family prophage protein; Prophage NinE homolog; Similar to phage 82 and lambda proteins
DLP12 prophage; DNA base-flipping protein; Uncharacterized protein YbcN; Phage or Prophage Related
Uncharacterized protein YlcG; Phage or Prophage Related; To equivalent protein in phage 82
DLP12 prophage; uncharacterized protein YlcH; Uncharacterized protein YlcH; Phage or Prophage Related
Periplasmic inhibitor of g-type lysozyme; Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium
DLP12 prophage; putative antitermination protein; Positively regulate expression of some phage genes. Bacterial host RNA polymerase modified by antitermination proteins transcribes through termination sites that otherwise prevent expression of the regulated genes (By similarity)
9-O-acetyl-N-acetylneuraminic acid deacetylase; Probably catalyzes the hydrolysis of the 9-O-acetyl group of 9-O-acetyl-N-acetylneuraminate (Neu5,9Ac2). Is required for growth of E.coli on Neu5,9Ac2, an alternative sialic acid commonly found in mammalian host mucosal sites, in particular in the human intestine
Iron-dependent inhibitor of iron-sulfur cluster formation; Involved in iron-sulfur (Fe-S) cluster assembly . May act as a regulator of Fe-S biogenesis Can bind both Fe(2+) and Fe(3+) ions . In vivo, has a positive effect on Fe-S cluster biogenesis under iron- rich growth conditions . In vitro, can inhibit IscS cysteine desulfurase activity and the formation of Fe-S clusters on IscU . In vitro, in the presence of IscS and cysteine, Fe(3+)-CyaY can be used as an iron donor during Fe-S cluster assembly on the scaffold protein IscU
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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