STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
appYArac family transcriptional regulator, transcriptional regulator required for anaerobic and stationary phase induction of genes; Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions (249 aa)    
Predicted Functional Partners:
DLP12 prophage; putative prophage endopeptidase RzpD; Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the murein component of the bacterial cell wall (By similarity)
Periplasmic AppA protein; Phosphoanhydride phosphorylase; pH 2.5 acid phosphatase; periplasmic; Protein involved in phosphorus metabolic process and response to starvation
CP4-57 prophage; DNA-binding transcriptional activator AlpA; Positive regulator of the expression of the slpA gene . When overexpressed, leads to suppression of the capsule overproduction and UV sensitivity phenotypes of cells mutant for the Lon ATP-dependent protease . Part of the cryptic P4-like prophage CP4-57 . Overexpression of AlpA leads to excision of the CP4-57 prophage by IntA. This inactivates ssrA (the gene upstream of the prophage) that encodes tmRNA which is required to rescue stalled ribosomes in a process known as trans- translation
CP4-57 prophage; putative antitoxin of the YpjF-YfjZ toxin-antitoxin system; Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of cognate toxin YpjF . Also counteracts the effect of non-cognate toxins CbtA and YfkI
Anti-adaptor protein irad, inhibitor of sigma(s) proteolysis; Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway
Rna polymerase nonessential primary-like sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management
Anti-adaptor protein iram, inhibitor of sigma(s) proteolysis; Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation. May also be involved in the early steps of isoprenoid biosynthesis, possibly through its role as RssB regulator
Haemolysin expression modulating protein; Down-regulates hemolysin (hly) expression in complex with H- NS . Stimulates transposition events in vivo . Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Binds DNA and influences DNA topology in response to environmental stimuli; does not however interact with DNA in the absence of H-NS . Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR . Decreases biofilm formation by [...]
Isoprenoid biosynthesis protein with amidotransferase-like domain; Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate . However, this apparent glyoxalase activity may reflect a protein deglycase activity, which could be the primary function of this protein like other DJ-1 superfamily members such as PARK7, YajL, YhbO and HchA (Probable). Is not able to use methylglyoxal as substrate
DLP12 prophage; putative phage lysis protein; Prophage lysis protein S homolog EssD; Phage or Prophage Related
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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