node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
baeR | cusS | b2079 | b0570 | Response regulator in two-component regulatory system with BaeS; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon. | Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | 0.812 |
baeR | yedW | b2079 | b1969 | Response regulator in two-component regulatory system with BaeS; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon. | Response regulator family protein; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Regulates the expression of at least 5 operons, cyoABCDE, hprRS, hiuH, cusRS and cusCFBA. Bifunctional regulator that acts as an activator and a repressor. | 0.404 |
cpxR | cusS | b3912 | b0570 | Response regulator in two-component regulatory system with CpxA; Response regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation. Induced upon cell surface binding, subsequently induces genes it controls (cpxP, dsbA and spy, degP is only partially induced). Binds and activates transcription from the degP promoter ; binding is enhan [...] | Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | 0.825 |
cpxR | ompR | b3912 | b3405 | Response regulator in two-component regulatory system with CpxA; Response regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation. Induced upon cell surface binding, subsequently induces genes it controls (cpxP, dsbA and spy, degP is only partially induced). Binds and activates transcription from the degP promoter ; binding is enhan [...] | Response regulator in two-component regulatory system with EnvZ; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes. Plays a central role in both acid and osmotic stress responses. Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription. Involved in acid stress response; this requires EnvZ but not OmpR phosphorylation. Phosphorylated by EnvZ; this stimulates OmpR's DNA-binding abi [...] | 0.641 |
cueO | cusA | b0123 | b0575 | Multicopper oxidase (laccase); Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm. | Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.905 |
cueO | cusB | b0123 | b0574 | Multicopper oxidase (laccase); Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm. | Copper/silver efflux system, membrane fusion protein; Part of a cation efflux system that mediates resistance to copper and silver. | 0.817 |
cueO | cusC | b0123 | b0572 | Multicopper oxidase (laccase); Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm. | Copper/silver efflux system, outer membrane component; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis. | 0.823 |
cueO | cusF | b0123 | b0573 | Multicopper oxidase (laccase); Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm. | Periplasmic copper- and silver-binding protein; Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide. | 0.898 |
cueO | cusR | b0123 | b0571 | Multicopper oxidase (laccase); Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm. | Response regulator in two-component regulatory system with CusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Activates the expression of cusCFBA, hiuH and plasmid pRJ1004 gene pcoE in response to increasing levels of copper or silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD. | 0.878 |
cueO | cusS | b0123 | b0570 | Multicopper oxidase (laccase); Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm. | Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | 0.812 |
cusA | cueO | b0575 | b0123 | Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Multicopper oxidase (laccase); Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm. | 0.905 |
cusA | cusB | b0575 | b0574 | Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Copper/silver efflux system, membrane fusion protein; Part of a cation efflux system that mediates resistance to copper and silver. | 0.999 |
cusA | cusC | b0575 | b0572 | Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Copper/silver efflux system, outer membrane component; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis. | 0.999 |
cusA | cusF | b0575 | b0573 | Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Periplasmic copper- and silver-binding protein; Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide. | 0.999 |
cusA | cusR | b0575 | b0571 | Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Response regulator in two-component regulatory system with CusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Activates the expression of cusCFBA, hiuH and plasmid pRJ1004 gene pcoE in response to increasing levels of copper or silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD. | 0.955 |
cusA | cusS | b0575 | b0570 | Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | 0.951 |
cusB | cueO | b0574 | b0123 | Copper/silver efflux system, membrane fusion protein; Part of a cation efflux system that mediates resistance to copper and silver. | Multicopper oxidase (laccase); Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm. | 0.817 |
cusB | cusA | b0574 | b0575 | Copper/silver efflux system, membrane fusion protein; Part of a cation efflux system that mediates resistance to copper and silver. | Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.999 |
cusB | cusC | b0574 | b0572 | Copper/silver efflux system, membrane fusion protein; Part of a cation efflux system that mediates resistance to copper and silver. | Copper/silver efflux system, outer membrane component; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis. | 0.999 |
cusB | cusF | b0574 | b0573 | Copper/silver efflux system, membrane fusion protein; Part of a cation efflux system that mediates resistance to copper and silver. | Periplasmic copper- and silver-binding protein; Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide. | 0.999 |