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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cusRTwo-component system, ompr family, copper resistance phosphate regulon response regulator cusr; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Activates the expression of cusCFBA, hiuH and plasmid pRJ1004 gene pcoE in response to increasing levels of copper or silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD (227 aa)    
Predicted Functional Partners:
cusS
Copper-sensing histidine kinase in two-component regulatory system with cusr; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation
 0.999
cusC
Copper/silver efflux system, outer membrane component; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis
 
  
 0.988
cusF
Copper/silver export system periplasmic binding protein; Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide
 
  
 0.973
cusB
Copper/silver efflux system, membrane fusion protein; Part of a cation efflux system that mediates resistance to copper and silver
 
  
 0.969
cusA
Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver
 
  
 0.957
yedV
Putative sensory kinase in two-component regulatory system with yedw; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide Senses H(2)O(2), maybe via the redox state of the membrane . Activates HprR by phosphorylation . Can also phosphorylate CusR
 
 
 0.930
cueR
Merr family transcriptional regulator, copper efflux regulator; Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations
   
 
 0.891
cueO
Cuprous oxidase/multicopper oxidase with role in copper homeostasis; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm
     
 0.889
zraS
Sensory histidine kinase in two-component regulatory system with zrar; Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium
 
 
 0.742
baeS
Sensory histidine kinase in two-component regulatory system with baer; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress . Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression . Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons
 
 
 0.675
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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