Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
query proteins and first shell of interactors
second shell of interactors
proteins of unknown 3D structure
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
|rsfS||Functions as a ribosomal silencing factor. Addition to isolated ribosomal subunits partially inhibits their association, preventing translation. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8, preventing association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (105 aa)|| |
Predicted Functional Partners:
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. Specific for fully assembled 70S ribosomes.
| || || ||0.996
This protein binds directly to 23S ribosomal RNA. In the E.coli 70S ribosome it has been modeled to make two contacts with the 16S rRNA of the 30S subunit, forming part of bridges B5 and B8, connecting the 2 subunits . Although the protein undergoes significant rotation during the transition from an initiation to and EF-G bound state, the bridges remain stable. In the 3.5 A resolved structures L14 and L19 interact and together make contact with the 16S rRNA in bridges B5 and B8 .
| || || || || ||0.993
One of the primary rRNA binding proteins, it binds close to the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly
| || || ||0.929
Catalyzes cross-linking of the peptidoglycan cell wall . Responsible for the determination of the rod shape of the cell . Is probably required for lateral peptidoglycan synthesis and maintenance of the correct diameter during lateral and centripetal growth .
| || || || || ||0.877
50S ribosomal protein L27; Protein involved in structural constituent of ribosome and translation
| || || || ||0.872
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
| || || || || ||0.863
50S ribosomal protein L32; Protein involved in structural constituent of ribosome and translation
| || || || ||0.859
annotation not available
| || || || || ||0.845
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
| || || || || || ||0.833
Peptidoglycan polymerase that is essential for cell wall elongation . Also required for the maintenance of the rod cell shape . Functions probably in conjunction with the penicillin-binding protein 2 (mrdA) (PubMed:2644207, PubMed:27643381)
| || || || || || ||0.824
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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