Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| apaG | ybeX | b0050 | b0658 | annotation not available | Magnesium and cobalt transporter; Plays a role in the transport of magnesium and cobalt ions | 0.605 |
| dnaJ | dnaK | b0015 | b0014 | Chaperone hsp40, dnak co-chaperone; Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK t [...] | Chaperone hsp70, with co-chaperone dnaj; Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock | 0.999 |
| dnaJ | gyrA | b0015 | b2231 | Chaperone hsp40, dnak co-chaperone; Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK t [...] | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | 0.897 |
| dnaJ | gyrB | b0015 | b3699 | Chaperone hsp40, dnak co-chaperone; Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK t [...] | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | 0.915 |
| dnaJ | leuS | b0015 | b0642 | Chaperone hsp40, dnak co-chaperone; Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK t [...] | Leucyl-trna synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family | 0.601 |
| dnaJ | miaB | b0015 | b0661 | Chaperone hsp40, dnak co-chaperone; Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK t [...] | TRNA-2-methylthio-N6-dimethylallyladenosine synthase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine | 0.449 |
| dnaJ | ybeX | b0015 | b0658 | Chaperone hsp40, dnak co-chaperone; Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK t [...] | Magnesium and cobalt transporter; Plays a role in the transport of magnesium and cobalt ions | 0.577 |
| dnaJ | ybeY | b0015 | b0659 | Chaperone hsp40, dnak co-chaperone; Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK t [...] | Probable rrna maturation factor; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. Acts together with the RNase R to eliminate defective 70S ribosomes, but not properly matured 70S ribosomes or individual subunits, by a process mediated specifically by the 30S ribosomal subunit. Involved in the processing of 16S, 23S and 5S rRNAs, with a particularly strong effect on maturation at both the 5'- and 3'- ends of 16S rRNA as well as maturation of the 5'-end of 23S and 5S rRNAs | 0.448 |
| dnaK | dnaJ | b0014 | b0015 | Chaperone hsp70, with co-chaperone dnaj; Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock | Chaperone hsp40, dnak co-chaperone; Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK t [...] | 0.999 |
| dnaK | gyrA | b0014 | b2231 | Chaperone hsp70, with co-chaperone dnaj; Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | 0.985 |
| dnaK | gyrB | b0014 | b3699 | Chaperone hsp70, with co-chaperone dnaj; Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | 0.959 |
| dnaK | leuS | b0014 | b0642 | Chaperone hsp70, with co-chaperone dnaj; Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock | Leucyl-trna synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family | 0.726 |
| dnaK | ybeX | b0014 | b0658 | Chaperone hsp70, with co-chaperone dnaj; Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock | Magnesium and cobalt transporter; Plays a role in the transport of magnesium and cobalt ions | 0.547 |
| dnaK | ybeZ | b0014 | b0660 | Chaperone hsp70, with co-chaperone dnaj; Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock | Phosphate starvation-inducible protein phoh and related proteins; Belongs to the PhoH family | 0.465 |
| gyrA | dnaJ | b2231 | b0015 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | Chaperone hsp40, dnak co-chaperone; Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK t [...] | 0.897 |
| gyrA | dnaK | b2231 | b0014 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | Chaperone hsp70, with co-chaperone dnaj; Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock | 0.985 |
| gyrA | gyrB | b2231 | b3699 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | 0.999 |
| gyrA | leuS | b2231 | b0642 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | Leucyl-trna synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family | 0.779 |
| gyrA | ybeX | b2231 | b0658 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | Magnesium and cobalt transporter; Plays a role in the transport of magnesium and cobalt ions | 0.542 |
| gyrB | dnaJ | b3699 | b0015 | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | Chaperone hsp40, dnak co-chaperone; Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK t [...] | 0.915 |
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