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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
asnBAsparagine synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent conversion of aspartate into asparagine, using glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro, albeit with lower efficiency. As nucleotide substrates, ATP and dATP are utilized at a similar rate in both the glutamine- and ammonia-dependent reactions, whereas GTP utilization is only 15% that of ATP, and CTP, UTP, ITP and XTP are very poor or not substrates. Also exhibits glutaminase activity (554 aa)    
Predicted Functional Partners:
asnA
Aspartate--ammonia ligase; May amidate Asp of the extracellular death factor precursor Asn-Asn-Trp-Asp-Asn to generate Asn-Asn-Trp-Asn-Asn
   
 
 0.981
argG
Argininosuccinate synthetase; Belongs to the argininosuccinate synthase family. Type 2 subfamily
   
 0.970
thrA
Bifunctional aspartokinase / homoserine dehydrogenase 1; In the C-terminal section; belongs to the homoserine dehydrogenase family
 
 
 0.959
metL
Bifunctional aspartokinase / homoserine dehydrogenase 2; In the N-terminal section; belongs to the aspartokinase family
 
 
 0.949
ansB
Periplasmic l-asparaginase 2; Belongs to the asparaginase 1 family
   
 
 0.934
ansA
Cytoplasmic l-asparaginase 1; Belongs to the asparaginase 1 family
   
 
 0.933
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
  
 
 0.929
pyrB
Aspartate carbamoyltransferase catalytic subunit; Enzyme; Pyrimidine ribonucleotide biosynthesis; Belongs to the ATCase/OTCase family
  
 
 0.926
aspA
Aspartate ammonia-lyase (aspartase); Protein involved in cellular amino acid metabolic process, asparagine biosynthetic process and lysine biosynthetic process via diaminopimelate
     
 0.921
aspC
Aspartate aminotransferase, plp-dependent; Aspartate aminotransferase; Protein involved in cellular amino acid catabolic process and aspartate biosynthetic process
   
 
 0.915
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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