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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mngRGntr family transcriptional regulator, mannosyl-d-glycerate transport/metabolism system repressor; Represses mngA and mngB. Regulates its own expression (240 aa)    
Predicted Functional Partners:
mngB
Mannosylglycerate hydrolase; May hydrolyze 6-phospho-mannosyl-D-glycerate to mannose-6- phosphate and glycerate
 
  
 0.897
mngA
Fused 2-o-a-mannosyl-d-glycerate specific pts enzymes: iia component/iib component/iic component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane . This system is involved in mannosyl- D-glycerate transport . Also involved in thermoinduction of ompC
 
   
 0.887
ulaR
Deor family transcriptional regulator, ulag and ulaabcdef operon transcriptional repressor; Represses ulaG and the ulaABCDEF operon. Two ulaR binding sites have been identified in each promoter. Full activity requires simultaneous interaction of UlaR with both divergent promoters and seems to be dependent on repressor-mediated DNA loop formation, which is helped by the action of integration host factor
      
 0.549
csiR
Gntr family transcriptional regulator, carbon starvation induced regulator; Negatively regulates the expression of the glaH-lhgD-gabDTP operon in a temporal manner during entry into stationary phase or during the first few hours of carbon starvation Thereby is involved in the regulation of a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2- hydroxyglutarate . Binds to two primary and two secondary sites in the promoter region of the glaH operon with the consensus sequences TTGTN5TTTT and ATGTN5TTTT of the primary sites, each separated by six nucleotides
      
 0.534
gntR
Laci family transcriptional regulator, gluconate utilization system gnt-i transcriptional repressor; Negative regulator for the gluconate utilization system GNT- I, the gntUKR operon
  
   
 0.524
argR
L-arginine-responsive arginine metabolism regulon transcriptional regulator; Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1
      
 0.502
marR
Marr family transcriptional regulator, multiple antibiotic resistance protein marr; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site
      
 0.484
bglF
Fused beta-glucoside-specific pts enzymes: iia component/iib component/iic component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in beta-glucoside transport
 
   
 0.478
yihW
Putative transcriptional regulator for sulphoquinovose utilization; Involved in the regulation of the sulfoquinovose operon . Represses the expression of the yihUTS operon and of the yihV and csqR genes. Binds DNA inside the spacer between the bidirectional transcription units comprising the yihUTS operon and the yihV gene, and upstream the csqR gene itself
  
   
 0.463
ascG
Laci family transcriptional regulator, asc operon repressor; Repressor of the asc operon. The cryptic operon is activated by the insertion of IS186 into the ascG gene
  
   
 0.460
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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