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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mngAFused 2-o-a-mannosyl-d-glycerate specific pts enzymes: iia component/iib component/iic component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane . This system is involved in mannosyl- D-glycerate transport . Also involved in thermoinduction of ompC (658 aa)    
Predicted Functional Partners:
mngB
Mannosylglycerate hydrolase; May hydrolyze 6-phospho-mannosyl-D-glycerate to mannose-6- phosphate and glycerate
 
   
 0.953
ptsH
Phosphohistidinoprotein-hexose phosphotransferase component of pts system (hpr); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain
   
 0.945
fruK
fructose-1-phosphate kinase; Belongs to the carbohydrate kinase PfkB family
 
  
 0.906
fruB
Fused fructose-specific pts enzymes: iia component/hpr component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport
 
 
 0.900
mngR
Gntr family transcriptional regulator, mannosyl-d-glycerate transport/metabolism system repressor; Represses mngA and mngB. Regulates its own expression
 
   
 0.887
pfkB
6-phosphofructokinase 2; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
 
  
 0.884
nagE
N-acetyl glucosamine specific pts enzyme iic, iib, and iia components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane . This system is involved in N-acetylglucosamine transport . It can also transport and phosphorylate the antibiotic streptozotocin . Could play a significant role in the recycling of peptidoglycan
   
 
 0.832
dhaM
Putative dihydroxyacetone-specific pts enzymes: hpr, ei components; Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone
  
 
 0.785
frvR
Putative transcriptional regulator frvr; Could be involved in the regulation of the transcription of the FRV operon
   
 
 0.753
bglF
Fused beta-glucoside-specific pts enzymes: iia component/iib component/iic component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in beta-glucoside transport
   
 
 0.747
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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