node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acrA | acrB | b0463 | b0462 | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | Multidrug efflux system protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. | 0.999 |
acrA | acrZ | b0463 | b0762 | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | 0.991 |
acrA | tolC | b0463 | b3035 | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | Transport channel; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. | 0.999 |
acrB | acrA | b0462 | b0463 | Multidrug efflux system protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | 0.999 |
acrB | acrZ | b0462 | b0762 | Multidrug efflux system protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | 0.993 |
acrB | tolC | b0462 | b3035 | Multidrug efflux system protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. | Transport channel; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. | 0.999 |
acrZ | acrA | b0762 | b0463 | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | 0.991 |
acrZ | acrB | b0762 | b0462 | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | Multidrug efflux system protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. | 0.993 |
acrZ | cydX | b0762 | b4515 | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | Cytochrome d (bd-I) ubiquinol oxidase subunit X; Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap. | 0.858 |
acrZ | kdpF | b0762 | b4513 | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | Potassium ion accessory transporter subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit may be involved in stabilization of the complex. | 0.644 |
acrZ | mntS | b0762 | b4705 | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | Mn(2)-response protein, MntR-repressed; Required for repression of mntH by MntR. May function as a chaperone that makes manganese more available by delivering it to the necessary cellular locations when manganese is limiting. | 0.712 |
acrZ | modE | b0762 | b0761 | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | Transcriptional repressor for the molybdenum transport operon modABC; Functions as an intracellular molybdate sensor. The ModE-Mo complex acts as a repressor of the modABC operon, which is involved in the transport of molybdate. Binds modA promoter DNA in the absence of molybdate, however molybdate binding confers increased DNA affinity. Binds the promoter of moaA activating its transcription; binding is not enhanced by molybdate. The protein dimer binds the consensus palindrome sequence 5'-TATAT-N7-TAYAT-3' and a variant 5'-TGTGT-N7-TGYGT-3'. Acts as a regulator of the expression of 6 [...] | 0.607 |
acrZ | sgrT | b0762 | b4662 | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | Inhibitor of glucose uptake; Acts to promote recovery from glucose-phosphate stress due to intracellular accumulation of glucose-6-phosphate caused by disruption of glycolytic flux or in the presence of (toxic) non-metabolizable glucose phosphate analogs. It may do so by inhibiting the transporter activity for glucose uptake (PtsG) as cells that overexpress this protein do not seem to import glucose although they have nearly wild- type levels of PtsG. | 0.733 |
acrZ | tolC | b0762 | b3035 | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | Transport channel; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. | 0.973 |
acrZ | yneM | b0762 | b4599 | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | Inner membrane-associated protein; Modulates intracellular Mg(2+) levels to maintain cellular integrity upon Mg(2+) limitation. Acts by binding and stabilizing the Mg(2+) transporter MgtA, thereby leading to increased intracellular level of Mg(2+). May inhibit FtsH proteolysis of MgtA. | 0.730 |
acrZ | yqcG | b0762 | b4682 | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | Membrane stress resistance protein. | 0.620 |
cydX | acrZ | b4515 | b0762 | Cytochrome d (bd-I) ubiquinol oxidase subunit X; Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap. | AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. | 0.858 |
cydX | kdpF | b4515 | b4513 | Cytochrome d (bd-I) ubiquinol oxidase subunit X; Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap. | Potassium ion accessory transporter subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit may be involved in stabilization of the complex. | 0.529 |
cydX | mntS | b4515 | b4705 | Cytochrome d (bd-I) ubiquinol oxidase subunit X; Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap. | Mn(2)-response protein, MntR-repressed; Required for repression of mntH by MntR. May function as a chaperone that makes manganese more available by delivering it to the necessary cellular locations when manganese is limiting. | 0.808 |
cydX | sgrT | b4515 | b4662 | Cytochrome d (bd-I) ubiquinol oxidase subunit X; Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap. | Inhibitor of glucose uptake; Acts to promote recovery from glucose-phosphate stress due to intracellular accumulation of glucose-6-phosphate caused by disruption of glycolytic flux or in the presence of (toxic) non-metabolizable glucose phosphate analogs. It may do so by inhibiting the transporter activity for glucose uptake (PtsG) as cells that overexpress this protein do not seem to import glucose although they have nearly wild- type levels of PtsG. | 0.644 |