STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ybhFABC-2 type transport system ATP-binding protein; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably responsible for energy coupling to the transport system (578 aa)    
Predicted Functional Partners:
ybhS
ABC-2 type transport system permease protein; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane
 0.998
ybhR
ABC-2 type transport system permease protein; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane
 0.997
ybhG
Putative membrane fusion protein (mfp) component of efflux pump, membrane anchor; Could be involved in the sensitivity control to chloramphenicol
 
 0.988
ybiH
Tetr/acrr family transcriptional regulator, regulator of cefoperazone and chloramphenicol sensitivity; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons
 
  
 0.936
yhhJ
ABC-2 type transport system permease protein; Inner membrane transport permease YhhJ; Putative transporter
 
 0.858
queF
7-cyano-7-deazaguanine reductase (NADPH-dependent); Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1), a late step in the queuosine pathway. Is highly specific for its natural substrate preQ0, since it cannot use various aliphatic, aromatic, benzylic and heterocyclic nitriles, such as acetonitrile, benzonitrile, benzylcyanide and 2-cyanopyrrole, although it can reduce the substrate analog 5-cyanopyrrolo[2,3-d]pyrimidin-4-one with lesser efficiency
  
  
 0.785
yhiI
Putative membrane fusion protein (mfp) of efflux pump; Uncharacterized protein YhiI; Putative membrane protein
 
 0.770
mdtO
Membrane translocase (mdr) of mdtnop efflux pump, pet family; Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
      
 0.671
pqqL
Putative periplasmic m16 family zinc metalloendopeptidase; Putative zinc protease
      
 0.619
hyfA
Hydrogenase 4, 4fe-4s subunit; Probable electron transfer protein for hydrogenase 4
     
 0.610
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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