STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ybiHTetr/acrr family transcriptional regulator, regulator of cefoperazone and chloramphenicol sensitivity; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons (223 aa)    
Predicted Functional Partners:
ybhG
Putative membrane fusion protein (mfp) component of efflux pump, membrane anchor; Could be involved in the sensitivity control to chloramphenicol
 
  
 0.985
ybhR
ABC-2 type transport system permease protein; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane
 
  
 0.971
ybhF
ABC-2 type transport system ATP-binding protein; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably responsible for energy coupling to the transport system
 
  
 0.936
ybhS
ABC-2 type transport system permease protein; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane
 
    0.934
bdcR
Tetr/acrr family transcriptional regulator, repressor for divergent bdca; Negatively regulates expression of bdcA
      
 0.873
yddM
Putative dna-binding transcriptional regulator yddm; Belongs to the VapA/VapI family
      
 0.815
ybaO
Putative dna-binding transcriptional regulator; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. No other DNA target was identified in strain K12 / BW25113. Thiosulfate does not activate its transcription function. Overexpression doubles hydrogen sulfide production in the presence of cysteine
   
  
 0.793
yjdC
Putative dna-binding transcriptional regulator yjdc; HTH-type transcriptional regulator YjdC; Anticodon: GAA
  
   
 0.784
yiaJ
Iclr family transcriptional regulator, carbohydrate utilization repressor; Negatively controls the transcription of the yiaKLMNOPQRS operon, which may be involved in the utilization of 2,3-diketo-L- gulonate
      
 0.780
ydcI
Putative dna-binding transcriptional repressor ydci; Belongs to the LysR transcriptional regulatory family
  
   
 0.768
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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