STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mcbAMqsr-controlled colanic acid and biofilm protein a; Affects biofilm formation and mucoidy (86 aa)    
Predicted Functional Partners:
pmbA
Putative antibiotic peptide mccb17 maturation peptidase; Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA)
      
 0.876
mcbR
Gntr family transcriptional regulator, colanic acid and biofilm gene transcriptional regulator; Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy
      
 0.874
yjfY
annotation not available
  
  
 0.855
yhcN
annotation not available
  
   
 0.754
tldD
Metalloprotease tldd; Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA)
      
 0.735
rclB
Reactive chlorine species (rcs) stress resistance periplasmic protein; Probably involved in reactive chlorine species (RCS) stress resistance
      
 0.732
mqsR
Toxic component of a type II toxin-antitoxin (TA) system. Plays a significant role in the control of biofilm formation and induction of persister cells in the presence of antibiotics. An mRNA interferase which has been reported to be translation-independent . It has also been reported to be translation-dependent . Cleavage has been reported to occur on either side of G in the sequence GCU . Also reported to cleave after C in GC(A/U) sequences . There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interfera [...]
      
 0.732
ycaO
Ribosomal protein s12 methylthiotransferase accessory factor ycao; Involved in beta-methylthiolation of ribosomal protein S12
      
 0.703
ydgH
DUF1471 domain-containing protein YdgH; To E.coli YjfY
  
   
 0.699
yjfN
annotation not available
  
   
 0.690
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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