STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mntRIn the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP. (155 aa)    
Predicted Functional Partners:
mntH
H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen
 
   
 0.963
mntS
Required for repression of mntH by MntR. May function as a chaperone that makes manganese more available by delivering it to the necessary cellular locations when manganese is limiting.
     
 0.937
mntP
Probably functions as a manganese efflux pump.
 
   
 0.930
hycG
Formate hydrogenlyase subunit 7; Hydrogenase activity; Protein involved in fermentation and anaerobic respiration
    
 
 0.882
perR
Apparent regulatory gene involved in peroxide resistance in stationary phase
    
 
 0.875
metN
Part of the ABC transporter complex MetNIQ involved in methionine import (PubMed:12169620, PubMed:12218041, PubMed:12819857, PubMed:18621668, PubMed:30352853). Responsible for energy coupling to the transport system . It has also been shown to be involved in formyl-L-methionine transport . ECO:0000269|PubMed:12218041, ECO:0000269|PubMed:12819857, ECO:0000269|PubMed:18621668, ECO:0000269|PubMed:25678706,
    
   0.870
ybiR
annotation not available
  
    0.866
yjhC
Belongs to the Gfo/Idh/MocA family
    
 
 0.815
znuB
Involved in the high-affinity zinc uptake transport system
     
 0.738
zntR
Zinc-responsive transcriptional regulator of zntA
      
 0.702
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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