STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ldtBProbable L,D-transpeptidase YbiS; Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L- Lys- bond on the terminal residue of Lpp. Can be oxidized in vivo, its reduction depends preferentially on DsbG, although DsbC is able to partially replace DsbG; Belongs to the YkuD family (306 aa)    
Predicted Functional Partners:
dacA
D-alanyl-D-alanine carboxypeptidase DacA; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
   
 
  0.914
ampH
D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH; Hydrolyzes the cross-linked dimers tetrapentapeptide (D45) and tetratetrapeptide (D44). Removes the terminal D-alanine from muropeptides and disaccharide pentapeptide M5 with a C- terminal D-Ala-D-Ala dipeptide. Associated with recycling and remodeling of peptidoglycan (PG). Also displays a low beta- lactamase activity; Belongs to the beta-lactamase family
     
  0.900
dacC
D-alanyl-D-alanine carboxypeptidase DacC; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
     
  0.900
dacD
D-alanyl-D-alanine carboxypeptidase DacD; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family
     
  0.900
yfeW
UPF0214 protein YfeW; Putative beta-lactamase; Protein involved in carbohydrate catabolic process; Belongs to the UPF0214 family
     
  0.900
rcnB
Nickel/cobalt homeostasis protein RcnB; Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly; Belongs to the RcnB family
    
 
 0.804
yebQ
Uncharacterized transporter YebQ; Putative transport protein
      
 0.750
yebO
annotation not available
      
 0.749
ydfG
NADP-dependent 3-hydroxy acid dehydrogenase YdfG; NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP- dependent oxidation of L-allo-threonine to L-2-amino-3-keto- butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3- hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L- glycerate. Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid. YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved i [...]
      
 0.680
yceO
annotation not available
      
 0.625
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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