STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ycaCPutative isochorismatase family hydrolase; Probable hydrolase YcaC; Protein involved in cellular amino acid catabolic process (208 aa)    
Predicted Functional Partners:
nnr
Adp-dependent nad(p)h-hydrate dehydratase / nad(p)h-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
  
    0.934
elaB
Putative membrane-anchored duf883 family ribosome-binding protein; Belongs to the ElaB/YgaM/YqjD family
   
  
 0.927
yebV
annotation not available
   
  
 0.876
ygaM
annotation not available
   
  
 0.857
msyB
Acidic protein that suppresses heat sensitivity of a secy mutant; Could participate in the normal pathway of protein export
   
    0.844
yiaG
HTH_CROC1 family putative transcriptional regulator; Uncharacterized HTH-type transcriptional regulator YiaG; Protein involved in regulation of transcription, DNA-dependent
   
    0.844
yegP
DUF1508 domain-containing protein YegP; Belongs to the UPF0339 family. Duplicated subfamily
  
    0.842
katE
Catalase hpii, heme d-containing; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide
   
 
 0.832
yccJ
annotation not available
   
  
 0.831
ygaU
Uncharacterized protein; Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) concentration. Binds a single K(+) ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb(+) and Cs(+), and NH(4)(+) . May be involved in the regulation of peptidoglycan cross-linking
  
  
 0.829
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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