STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
focAFormate channel foca; Involved in the bidirectional transport of formate (285 aa)    
Predicted Functional Partners:
pflB
Formate c-acetyltransferase 1, anaerobic; Formate acetyltransferase 1; Protein involved in anaerobic respiration and cellular amino acid catabolic process
 
  
 0.987
tdcE
2-ketobutyrate formate-lyase/pyruvate formate-lyase 4; Catalyzes the cleavage of 2-ketobutyrate to propionyl-CoA and formate. It can also use pyruvate as substrate
 
   
 0.873
fdhF
Formate dehydrogenase-h, selenopolypeptide subunit; Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors
 
   
 0.795
fhlA
Formate hydrogenlyase transcriptional activator; Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes. Also activates expression of hyf operon (encodes the silent hydrogenase-4 gene cluster)
      
 0.790
adhE
Acetaldehyde dehydrogenase / alcohol dehydrogenase; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction
 
  
 0.749
ldhA
Fermentative d-lactate dehydrogenase, nad-dependent; Fermentative lactate dehydrogenase
   
  
 0.735
hycA
Regulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence . Also down-regulates expression of the hyf operon
      
 0.705
pflA
Pyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
 
  
 0.689
grcA
Stress-induced alternate pyruvate formate-lyase subunit; Acts as a radical domain for damaged PFL and possibly other radical proteins
  
  
 0.598
hyfD
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4
     
 0.593
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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