Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cmk | gyrA | b0910 | b2231 | Cytidylate kinase; ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | 0.684 |
| cmk | ihfB | b0910 | b0912 | Cytidylate kinase; ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors | Integration host factor (ihf), dna-binding protein, beta subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the ori [...] | 0.954 |
| cmk | rpsA | b0910 | b0911 | Cytidylate kinase; ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors | Required for translation of most natural mRNAs except for leaderless mRNA Binds mRNA upstream of the Shine- Dalgarno (SD) sequence and helps it bind to the 30S ribosomal subunit; acts as an RNA chaperone to unfold structured mRNA on the ribosome but is not essential for mRNAs with strong SDs and little 5'-UTR structure, thus it may help fine-tune which mRNAs that are translated . Unwinds dsRNA by binding to transiently formed ssRNA regions; binds about 10 nucleotides . Has a preference for polypyrimidine tracts . Negatively autoregulates its own translation . In case of infection by ba [...] | 0.994 |
| cmk | serC | b0910 | b0907 | Cytidylate kinase; ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors | 3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Is involved in both pyridoxine and serine biosynthesis | 0.805 |
| cmk | ycaI | b0910 | b0913 | Cytidylate kinase; ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors | annotation not available | 0.518 |
| fis | gyrA | b3261 | b2231 | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | 0.466 |
| fis | ihfA | b3261 | b1712 | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | Integration host factor (ihf), dna-binding protein, alpha subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Binds to hundreds of transcriptionally inactive, AT-rich DNA sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism [...] | 0.818 |
| fis | ihfB | b3261 | b0912 | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | Integration host factor (ihf), dna-binding protein, beta subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the ori [...] | 0.759 |
| gyrA | cmk | b2231 | b0910 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | Cytidylate kinase; ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors | 0.684 |
| gyrA | fis | b2231 | b3261 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | 0.466 |
| gyrA | ihfB | b2231 | b0912 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | Integration host factor (ihf), dna-binding protein, beta subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the ori [...] | 0.741 |
| gyrA | rpsA | b2231 | b0911 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | Required for translation of most natural mRNAs except for leaderless mRNA Binds mRNA upstream of the Shine- Dalgarno (SD) sequence and helps it bind to the 30S ribosomal subunit; acts as an RNA chaperone to unfold structured mRNA on the ribosome but is not essential for mRNAs with strong SDs and little 5'-UTR structure, thus it may help fine-tune which mRNAs that are translated . Unwinds dsRNA by binding to transiently formed ssRNA regions; binds about 10 nucleotides . Has a preference for polypyrimidine tracts . Negatively autoregulates its own translation . In case of infection by ba [...] | 0.808 |
| gyrA | serC | b2231 | b0907 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | 3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Is involved in both pyridoxine and serine biosynthesis | 0.587 |
| ihfA | fis | b1712 | b3261 | Integration host factor (ihf), dna-binding protein, alpha subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Binds to hundreds of transcriptionally inactive, AT-rich DNA sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism [...] | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | 0.818 |
| ihfA | ihfB | b1712 | b0912 | Integration host factor (ihf), dna-binding protein, alpha subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Binds to hundreds of transcriptionally inactive, AT-rich DNA sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism [...] | Integration host factor (ihf), dna-binding protein, beta subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the ori [...] | 0.995 |
| ihfA | ygbF | b1712 | b2754 | Integration host factor (ihf), dna-binding protein, alpha subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Binds to hundreds of transcriptionally inactive, AT-rich DNA sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism [...] | CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids) . CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The Cas1-Cas2 complex is involved in CRISPR adaptation, the first stage of CRISPR immunity, being required for the addition/removal of CRISPR spacers at the leader end of the CRISPR locus . The C [...] | 0.800 |
| ihfA | ygbT | b1712 | b2755 | Integration host factor (ihf), dna-binding protein, alpha subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Binds to hundreds of transcriptionally inactive, AT-rich DNA sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism [...] | CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids) . CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The Cas1-Cas2 complex is involved in CRISPR adaptation, the first stage of CRISPR immunity, being required for the addition/removal of CRISPR spacers at the leader end of the CRISPR locus . The C [...] | 0.800 |
| ihfB | cmk | b0912 | b0910 | Integration host factor (ihf), dna-binding protein, beta subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the ori [...] | Cytidylate kinase; ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors | 0.954 |
| ihfB | fis | b0912 | b3261 | Integration host factor (ihf), dna-binding protein, beta subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the ori [...] | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | 0.759 |
| ihfB | gyrA | b0912 | b2231 | Integration host factor (ihf), dna-binding protein, beta subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the ori [...] | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | 0.741 |
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