node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
argS | asnS | b1876 | b0930 | Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | 0.980 |
argS | glnS | b1876 | b0680 | Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | Glutamine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | 0.991 |
argS | gltX | b1876 | b2400 | Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). | 0.981 |
argS | hisS | b1876 | b2514 | Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | Histidine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | 0.967 |
argS | ileS | b1876 | b0026 | Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). | 0.995 |
argS | leuS | b1876 | b0642 | Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | Leucine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.995 |
argS | metG | b1876 | b2114 | Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. | 0.992 |
argS | proS | b1876 | b0194 | Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] | 0.991 |
argS | thrS | b1876 | b1719 | Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). The rate-limiting step is amino acid activation in the presence of tRNA. The 2'-OH of the acceptor base (adenine 76, A76) of tRNA(Thr) and His-309 collaborate to transfer L-Thr to the tRNA; substitution of 2'-OH of A76 with hydrogen or fluorine decreases transfer efficiency 760 and 100-fold respectively. The zinc ion in the active site discriminates against charging of the isost [...] | 0.907 |
argS | tyrS | b1876 | b1637 | Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | tyrosyl-tRNA synthetase; Catalyzes the attachment of L-tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Can also mischarge tRNA(Tyr) with D-tyrosine, leading to the formation of D-tyrosyl-tRNA(Tyr), which can be hydrolyzed by the D-aminoacyl-tRNA deacylase. In vitro, can also use the non-natural amino acid azatyrosine. | 0.968 |
asnS | argS | b0930 | b1876 | Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | 0.980 |
asnS | glnS | b0930 | b0680 | Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | Glutamine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | 0.970 |
asnS | gltX | b0930 | b2400 | Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). | 0.959 |
asnS | hisS | b0930 | b2514 | Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | Histidine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | 0.942 |
asnS | ileS | b0930 | b0026 | Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). | 0.977 |
asnS | leuS | b0930 | b0642 | Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | Leucine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.978 |
asnS | metG | b0930 | b2114 | Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. | 0.982 |
asnS | proS | b0930 | b0194 | Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] | 0.974 |
asnS | thrS | b0930 | b1719 | Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). The rate-limiting step is amino acid activation in the presence of tRNA. The 2'-OH of the acceptor base (adenine 76, A76) of tRNA(Thr) and His-309 collaborate to transfer L-Thr to the tRNA; substitution of 2'-OH of A76 with hydrogen or fluorine decreases transfer efficiency 760 and 100-fold respectively. The zinc ion in the active site discriminates against charging of the isost [...] | 0.957 |
asnS | tyrS | b0930 | b1637 | Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. | tyrosyl-tRNA synthetase; Catalyzes the attachment of L-tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Can also mischarge tRNA(Tyr) with D-tyrosine, leading to the formation of D-tyrosyl-tRNA(Tyr), which can be hydrolyzed by the D-aminoacyl-tRNA deacylase. In vitro, can also use the non-natural amino acid azatyrosine. | 0.972 |