Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
query proteins and first shell of interactors
second shell of interactors
proteins of unknown 3D structure
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
|pncB||Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP (400 aa)|| |
Predicted Functional Partners:
Catalyzes the deamidation of nicotinamide (NAM) into nicotinate . Likely functions in the cyclical salvage pathway for production of NAD from nicotinamide
| || || ||0.996
Involved in the catabolism of quinolinic acid (QA).
| || || ||0.995
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
| || || || ||0.995
This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nic [...]
| || || || || ||0.992
Has nicotinamidemononucleotide (NMN) aminohydrolase activity, not active on other substrates
| || || || ||0.988
Asparagine--tRNA ligase; Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation
| || || || ||0.975
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
| || || ||0.960
Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates, but uniquely prefers the reduced form of NADH.
| || || || ||0.953
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
| || || || || || ||0.938
Catalyzes the oxidation of L-aspartate to iminoaspartate
| || || || || || ||0.937
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (9%) [HD]