STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hyaDPutative hydrogenase 1 maturation protease hyad; Protease involved in the C-terminal processing of HyaB, the large subunit of hydrogenase 1 (195 aa)    
Predicted Functional Partners:
hyaB
Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth
 
 
 0.999
hyaC
Ni/fe-hydrogenase 1 b-type cytochrome subunit; Probable b-type cytochrome
 
 0.999
hyaA
Hydrogenase 1, small subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth
 
 
 0.998
hyaE
Hydrogenase-1 operon protein HyaE; Not known. Could form, along with HyaD, a complex involved in the processing of the hydrogenase 1 structural operon
 
 
 0.998
hyaF
hydrogenase-1 protein nickel incorporation factor; Not known. Could enhance the incorporation of nickel to the hydrogenase
 
 
 0.998
cbdB
Cytochrome bd-ii ubiquinol oxidase subunit ii; A terminal oxidase that catalyzes quinol-dependent, Na(+)- independent oxygen uptake. Prefers menadiol over other quinols although ubiquinol was not tested . Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron
  
  
 0.896
hybC
Hydrogenase 2, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake
 
  
 0.874
hybO
Hydrogenase 2, small subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake
 
  
 0.829
cbdA
Cytochrome bd-ii ubiquinol oxidase subunit i; A terminal oxidase that catalyzes quinol-dependent, Na(+)- independent oxygen uptake. Prefers menadiol over other quinols although ubiquinol was not tested . Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron
  
  
 0.813
hybF
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. HybF is involved in maturation of hydrogenases 1 and 2. It may partially substitute for the function of HypA and vice versa
 
  
 0.766
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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