node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
efeB | efeO | b1019 | b1018 | Deferrrochelatase, periplasmic; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Also displays peroxidase activity on guaiacol in vitro. | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. | 0.999 |
efeB | fepA | b1019 | b0584 | Deferrrochelatase, periplasmic; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Also displays peroxidase activity on guaiacol in vitro. | Ferrienterobactin outer membrane transporter; This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D. | 0.496 |
efeB | fepB | b1019 | b0592 | Deferrrochelatase, periplasmic; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Also displays peroxidase activity on guaiacol in vitro. | Ferrienterobactin ABC transporter periplasmic binding protein; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. | 0.666 |
efeB | fiu | b1019 | b0805 | Deferrrochelatase, periplasmic; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Also displays peroxidase activity on guaiacol in vitro. | Catecholate siderophore receptor; Involved in the active transport across the outer membrane of iron complexed with catecholate siderophores such as dihydroxybenzoylserine and dihydroxybenzoate. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Can also transport catechol-substituted cephalosporins. Receptor for microcins M, H47 and E492. | 0.426 |
efeB | yfeX | b1019 | b2431 | Deferrrochelatase, periplasmic; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Also displays peroxidase activity on guaiacol in vitro. | Porphyrinogen oxidase, cytoplasmic; Has both general peroxidase activity and dye-decolorizing activity. Can catalyze the oxidation of both protoporphyrinogen IX and coproporphyrinogen III to their corresponding porphyrins. Also efficiently decolorizes the dyes alizarin red and Cibacron blue F3GA. | 0.925 |
efeB | yncE | b1019 | b1452 | Deferrrochelatase, periplasmic; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Also displays peroxidase activity on guaiacol in vitro. | ATP-binding protein, periplasmic, function unknown; Putative receptor. | 0.408 |
efeO | efeB | b1018 | b1019 | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. | Deferrrochelatase, periplasmic; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Also displays peroxidase activity on guaiacol in vitro. | 0.999 |
efeO | entE | b1018 | b0594 | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. | 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntE proccesses via a two-step adenylation-ligation reaction (bi-uni-uni-bi ping-pong mechanism). First, it catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate (D [...] | 0.586 |
efeO | exbD | b1018 | b3005 | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. | Membrane spanning protein in TonB-ExbB-ExbD complex; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. | 0.581 |
efeO | fepA | b1018 | b0584 | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. | Ferrienterobactin outer membrane transporter; This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D. | 0.632 |
efeO | fepB | b1018 | b0592 | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. | Ferrienterobactin ABC transporter periplasmic binding protein; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. | 0.602 |
efeO | fhuF | b1018 | b4367 | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. | Ferric iron reductase involved in ferric hydroximate transport; Involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. | 0.614 |
efeO | fiu | b1018 | b0805 | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. | Catecholate siderophore receptor; Involved in the active transport across the outer membrane of iron complexed with catecholate siderophores such as dihydroxybenzoylserine and dihydroxybenzoate. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Can also transport catechol-substituted cephalosporins. Receptor for microcins M, H47 and E492. | 0.777 |
efeO | yfeX | b1018 | b2431 | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. | Porphyrinogen oxidase, cytoplasmic; Has both general peroxidase activity and dye-decolorizing activity. Can catalyze the oxidation of both protoporphyrinogen IX and coproporphyrinogen III to their corresponding porphyrins. Also efficiently decolorizes the dyes alizarin red and Cibacron blue F3GA. | 0.793 |
efeO | yncE | b1018 | b1452 | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. | ATP-binding protein, periplasmic, function unknown; Putative receptor. | 0.850 |
efeO | yqjH | b1018 | b3070 | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. | Putative siderophore interacting protein; Plays a role in iron homeostasis under excess nickel conditions; Belongs to the SIP oxidoreductase family. | 0.571 |
entE | efeO | b0594 | b1018 | 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntE proccesses via a two-step adenylation-ligation reaction (bi-uni-uni-bi ping-pong mechanism). First, it catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate (D [...] | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. | 0.586 |
entE | exbD | b0594 | b3005 | 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntE proccesses via a two-step adenylation-ligation reaction (bi-uni-uni-bi ping-pong mechanism). First, it catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate (D [...] | Membrane spanning protein in TonB-ExbB-ExbD complex; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. | 0.486 |
entE | fepA | b0594 | b0584 | 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntE proccesses via a two-step adenylation-ligation reaction (bi-uni-uni-bi ping-pong mechanism). First, it catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate (D [...] | Ferrienterobactin outer membrane transporter; This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D. | 0.994 |
entE | fepB | b0594 | b0592 | 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntE proccesses via a two-step adenylation-ligation reaction (bi-uni-uni-bi ping-pong mechanism). First, it catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate (D [...] | Ferrienterobactin ABC transporter periplasmic binding protein; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. | 0.982 |