STRINGSTRING
ycdT protein (Escherichia coli K12 MG1655) - STRING interaction network
"ycdT" - Probable diguanylate cyclase YcdT in Escherichia coli K12 MG1655
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ycdTProbable diguanylate cyclase YcdT; A probable diguanylate cyclase, overexpression leads to a strong repression of swimming; swimming returns to normal when residues 359-360 are both mutated to Ala. Overexpression also leads to a 20-fold increase in c-di-GMP levels in vivo. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria (452 aa)    
Predicted Functional Partners:
yahA
Cyclic di-GMP phosphodiesterase YahA; Hydrolyzes c-di-GMP (cyclic bis(3’-5’) dimeric GMP) to 5’-pGpG, known as PDE-A activity. PDE-B activity, that is hydrolysis of 5’-pGpG to GMP, proceeds only very slowly (362 aa)
 
 
 
  0.951
yliE
Putative cyclic di-GMP phosphodiesterase YliE; Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria (782 aa)
 
 
 
  0.940
yhjK
annotation not available (662 aa)
 
 
  0.933
ycgG
Uncharacterized protein YcgG; Putative proteases (507 aa)
 
 
 
  0.931
yfeA
annotation not available (729 aa)
 
 
  0.906
ylaB
Putative cyclic-di-GMP phosphodiesterase YlaB; May function as a c-di-GMP phosphodiesterase. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria (By similarity) (516 aa)
 
     
  0.905
yoaD
Putative cyclic-di-GMP phosphodiesterase AdrB; May serve as a negative regulator of cellulose synthesis (as has been suggested for S.typhimurium); overexpression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria (532 aa)
 
 
  0.899
rtn
Protein Rtn; Involved in resistance to phages N4 and lambda (518 aa)
 
 
 
  0.891
pgaA
Poly-beta-1,6-N-acetyl-D-glucosamine export protein; Exports the biofilm adhesin polysaccharide poly-beta- 1,6-N-acetyl-D-glucosamine (PGA) across the outer membrane. The PGA transported seems to be partially N-deacetylated since N- deacetylation of PGA by PgaB is needed for PGA export through the PgaA porin (807 aa)
   
 
  0.880
csrD
RNase E specificity factor CsrD; Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility gene expression, is also required for curli expression (646 aa)
 
 
 
  0.866
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (16%) [HD]