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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clsCStationary phase cardiolipin synthase 3; Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE) (473 aa)    
Predicted Functional Partners:
ymdB
2'-O-acetyl-ADP-ribose deacetylase, regulator of RNase III activity; Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate . Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation . Overexpression inhibits biofilm formation via an RNase III-independent pathway. This inhibition is RpoS-dependent . Overexpression also results in increased susceptibility to apramycin
  
  
 0.991
pgpA
Phosphatidylglycerophosphatase a; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
     
 0.949
pgpC
Phosphatidylglycerophosphatase c, membrane bound; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
    
 0.926
pgpB
Phosphatidylglycerophosphatase b; Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are [...]
   
 0.912
clsB
Cardiolipin synthase a/b; Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Can also catalyze phosphatidyl group transfer to water to form phosphatidate
 
  
0.904
clsA
Cardiolipin synthase a/b; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
 
  
0.900
pgsA
CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids
  
 
 0.848
pssA
CDP-diacylglycerol--serine O-phosphatidyltransferase; Phosphatidylserine synthase; phospholipid synthesis; Protein involved in phospholipid biosynthetic process
      
 0.825
ynjF
Cdp-alcohol phosphatidyltransferase family inner membrane protein; Inner membrane protein YnjF; Putative cytochrome oxidase
  
 
 0.815
ymdA
annotation not available
     
 0.776
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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