STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yceDDUF177 domain-containing protein YceD; Plays a role in synthesis, processing and/or stability of 23S rRNA (173 aa)    
Predicted Functional Partners:
rpmF
Large subunit ribosomal protein l32; 50S ribosomal protein L32; Protein involved in structural constituent of ribosome and translation
  
  
 0.987
plsX
Putative phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
 
  
 0.957
rplU
Large subunit ribosomal protein l21; This protein binds to 23S rRNA in the presence of protein L20
  
    0.866
rplM
Large subunit ribosomal protein l13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
  
  
 0.861
trmD
Trna m(1)g37 methyltransferase, sam-dependent; Specifically methylates guanosine-37 in various tRNAs
  
    0.852
rpsJ
Small subunit ribosomal protein s10; Involved in the binding of tRNA to the ribosomes . In addition, in complex with NusB, is involved in the regulation of ribosomal RNA (rRNA) biosynthesis by transcriptional antitermination. S10 binds RNA non-specifically and increases the affinity of NusB for the boxA RNA sequence S10 may constitute the critical antitermination component of the NusB-S10 complex
   
   0.849
yjaG
Uncharacterized protein; To H.influenzae HI_0431
  
   
 0.843
rimM
One of at least 4 proteins (Era, RbfA, RimM and RsgA/YjeQ) that assist in the late assembly stage of the 30S ribosomal subunit. An accessory protein needed during the final step in assembly of the 30S ribosomal subunit, for assembly of the head region (the 16S rRNA 3' domain) It may act while Era is associated and before RimP in 30S subunit assembly . Interacts with S19 . Essential for efficient processing of 16S rRNA; a deletion mutant accumulates 17S rRNA . Deletions also do not assemble the head-associated ribosomal proteins correctly . May be needed both before and after RbfA durin [...]
  
    0.839
rpsL
Small subunit ribosomal protein s12; With S4 and S5 plays an important role in translational accuracy. Cryo-EM studies suggest that S12 contacts the EF-Tu bound tRNA in the A-site during codon-recognition. This contact is most likely broken as the aminoacyl-tRNA moves into the peptidyl transferase center in the 50S subunit
   
    0.832
rpmB
Large subunit ribosomal protein l28; 50S ribosomal protein L28; Protein involved in structural constituent of ribosome and translation
  
    0.831
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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