STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dhaLPhosphoenolpyruvate---glycerone phosphotransferase subunit dhal; ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone . DhaL-ADP is converted to DhaL- ATP via a phosphoryl group transfer from DhaM and transmits it to dihydroxyacetone bound to DhaK . DhaL acts also as coactivator of the transcription activator DhaR by binding to the sensor domain of DhaR . In the presence of dihydroxyacetone, DhaL-ADP displaces DhaK and stimulates DhaR activity . In the absence of dihydroxyacetone, DhaL-A [...] (210 aa)    
Predicted Functional Partners:
dhaM
Putative dihydroxyacetone-specific pts enzymes: hpr, ei components; Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone
 0.999
dhaK
Dihydroxyacetone kinase, pts-dependent, dihydroxyacetone-binding subunit; Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)- dependent phosphorylation of dihydroxyacetone via a phosphoryl group transfer from DhaL-ATP . Binds covalently dihydroxyacetone in hemiaminal linkage . DhaK acts also as corepressor of the transcription activator DhaR by binding to the sensor domain of DhaR . In the presence of dihydroxyacetone, DhaL-ADP displaces DhaK and stimulates DhaR activity . In the absence of dihydroxyacetone, DhaL- ADP [...]
 0.999
dhaR
Dna-binding transcriptional dual regulator dhar; Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own expression
 
 
 
 0.999
gldA
L-1,2-propanediol dehydrogenase/glycerol dehydrogenase; Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions. In E.coli, an important role of GldA is also likely to regulate the intracellular level of dihydroxyacetone by catalyzing the reverse reaction, i.e. the conversion of dihydroxyacetone into glycerol. Possesses a broad substrate specificity, since it is also able to oxidize 1,2-propanediol and to reduce glycolaldehyde, methylglyoxal and hydroxyacetone into ethy [...]
    
 0.916
gpsA
Glycerol-3-phosphate dehydrogenase (NAD(P)+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family
     
 0.804
glpA
Anaerobic sn-glycerol-3-phosphate dehydrogenase, large fad/nad(p)-binding subunit; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
 
  
 0.695
glpD
sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor
    
 0.647
glpB
Anaerobic sn-glycerol-3-phosphate dehydrogenase membrane anchor subunit; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
    
  0.630
glpC
Anaerobic sn-glycerol-3-phosphate dehydrogenase, c subunit, 4fe-4s iron-sulfur cluster; Electron transfer protein; may also function as the membrane anchor for the GlpAB dimer
   
 
  0.606
treA
Alpha,alpha-trehalase; Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
   
 
 0.571
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (2%) [HD]