node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
btuR | sohB | b1270 | b1272 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity). | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | 0.735 |
btuR | yciK | b1270 | b1271 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity). | Putative EmrKY-TolC system oxoacyl-(acyl carrier protein) reductase; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.969 |
btuR | ypfN | b1270 | b4547 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity). | Putative membrane protein, UPF0370 family. | 0.620 |
ptsP | sohB | b2829 | b1272 | PEP-protein phosphotransferase enzyme I; Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I-Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins. Enzyme I-Ntr is specific for NPr. | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | 0.412 |
rsmJ | sohB | b3497 | b1272 | 16S rRNA m(2)G1516 methyltransferase, SAM-dependent; Specifically methylates the guanosine in position 1516 of 16S rRNA; Belongs to the methyltransferase superfamily. RsmJ family. | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | 0.460 |
rsmJ | yidD | b3497 | b4557 | 16S rRNA m(2)G1516 methyltransferase, SAM-dependent; Specifically methylates the guanosine in position 1516 of 16S rRNA; Belongs to the methyltransferase superfamily. RsmJ family. | Membrane protein insertion efficiency factor, UPF0161 family inner membrane protein; Could be involved in insertion of integral membrane proteins into the membrane. | 0.704 |
sdhE | sohB | b2897 | b1272 | Flavinator of succinate dehydrogenase; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH. Required for flavinylation of th [...] | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | 0.607 |
sdhE | yqiB | b2897 | b3033 | Flavinator of succinate dehydrogenase; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH. Required for flavinylation of th [...] | DUF1249 protein YqiB; Putative enzyme. | 0.612 |
sohB | btuR | b1272 | b1270 | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity). | 0.735 |
sohB | ptsP | b1272 | b2829 | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | PEP-protein phosphotransferase enzyme I; Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I-Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins. Enzyme I-Ntr is specific for NPr. | 0.412 |
sohB | rsmJ | b1272 | b3497 | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | 16S rRNA m(2)G1516 methyltransferase, SAM-dependent; Specifically methylates the guanosine in position 1516 of 16S rRNA; Belongs to the methyltransferase superfamily. RsmJ family. | 0.460 |
sohB | sdhE | b1272 | b2897 | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | Flavinator of succinate dehydrogenase; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH. Required for flavinylation of th [...] | 0.607 |
sohB | topA | b1272 | b1274 | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | DNA topoisomerase I, omega subunit; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus re [...] | 0.666 |
sohB | trpC | b1272 | b1262 | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | Indole-3-glycerolphosphate synthetase and N-(5-phosphoribosyl)anthranilate isomerase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain. | 0.453 |
sohB | yciK | b1272 | b1271 | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | Putative EmrKY-TolC system oxoacyl-(acyl carrier protein) reductase; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.875 |
sohB | yidD | b1272 | b4557 | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | Membrane protein insertion efficiency factor, UPF0161 family inner membrane protein; Could be involved in insertion of integral membrane proteins into the membrane. | 0.550 |
sohB | ypfN | b1272 | b4547 | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | Putative membrane protein, UPF0370 family. | 0.624 |
sohB | yqiB | b1272 | b3033 | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | DUF1249 protein YqiB; Putative enzyme. | 0.444 |
topA | sohB | b1274 | b1272 | DNA topoisomerase I, omega subunit; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus re [...] | Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. | 0.666 |
topA | trpC | b1274 | b1262 | DNA topoisomerase I, omega subunit; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus re [...] | Indole-3-glycerolphosphate synthetase and N-(5-phosphoribosyl)anthranilate isomerase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain. | 0.459 |