Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gsiA | yciS | b0829 | b1279 | Glutathione abc transporter atp binding subunit gsia; Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system | DUF1049 family inner membrane protein, function unknown; Involved in the assembly of lipopolysaccharide (LPS) | 0.600 |
| hns | stpA | b1237 | b2669 | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | Dna-binding transcriptional repressor stpa with rna chaperone activity; A DNA-binding protein that acts in a fashion similar to H-NS protein upon overexpression, represses a number of genes including the cryptic blg operon, hns, papB and the proU locus . A subset of H-NS/StpA-regulated genes also require Hha for repression; Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Repression can be inhibited by dominant-negative mutants of StpA or H-NS | 0.874 |
| hns | yciM | b1237 | b1280 | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane | 0.533 |
| hns | yciS | b1237 | b1279 | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | DUF1049 family inner membrane protein, function unknown; Involved in the assembly of lipopolysaccharide (LPS) | 0.696 |
| hns | yfaL | b1237 | b2233 | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | Putative autotransporter adhesin yfal; Probably an autotransporter | 0.451 |
| hns | yhcB | b1237 | b3233 | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | annotation not available | 0.618 |
| pepA | yciS | b4260 | b1279 | Leucyl aminopeptidase; Probably involved in the processing and regular turnover of intracellular proteins . Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Required for plasmid ColE1 site-specific recombination but not in its aminopeptidase activity. Could act as a structural component of the putative nucleoprotein complex in which the Xer recombination reaction takes place | DUF1049 family inner membrane protein, function unknown; Involved in the assembly of lipopolysaccharide (LPS) | 0.732 |
| pgpB | yciM | b1278 | b1280 | Phosphatidylglycerophosphatase b; Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are [...] | Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane | 0.621 |
| pgpB | yciS | b1278 | b1279 | Phosphatidylglycerophosphatase b; Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are [...] | DUF1049 family inner membrane protein, function unknown; Involved in the assembly of lipopolysaccharide (LPS) | 0.699 |
| pyrF | yciM | b1281 | b1280 | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) | Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane | 0.627 |
| pyrF | yciS | b1281 | b1279 | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) | DUF1049 family inner membrane protein, function unknown; Involved in the assembly of lipopolysaccharide (LPS) | 0.624 |
| stpA | hns | b2669 | b1237 | Dna-binding transcriptional repressor stpa with rna chaperone activity; A DNA-binding protein that acts in a fashion similar to H-NS protein upon overexpression, represses a number of genes including the cryptic blg operon, hns, papB and the proU locus . A subset of H-NS/StpA-regulated genes also require Hha for repression; Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Repression can be inhibited by dominant-negative mutants of StpA or H-NS | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | 0.874 |
| stpA | yciS | b2669 | b1279 | Dna-binding transcriptional repressor stpa with rna chaperone activity; A DNA-binding protein that acts in a fashion similar to H-NS protein upon overexpression, represses a number of genes including the cryptic blg operon, hns, papB and the proU locus . A subset of H-NS/StpA-regulated genes also require Hha for repression; Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Repression can be inhibited by dominant-negative mutants of StpA or H-NS | DUF1049 family inner membrane protein, function unknown; Involved in the assembly of lipopolysaccharide (LPS) | 0.682 |
| stpA | yhcB | b2669 | b3233 | Dna-binding transcriptional repressor stpa with rna chaperone activity; A DNA-binding protein that acts in a fashion similar to H-NS protein upon overexpression, represses a number of genes including the cryptic blg operon, hns, papB and the proU locus . A subset of H-NS/StpA-regulated genes also require Hha for repression; Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Repression can be inhibited by dominant-negative mutants of StpA or H-NS | annotation not available | 0.461 |
| yciM | hns | b1280 | b1237 | Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | 0.533 |
| yciM | pgpB | b1280 | b1278 | Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane | Phosphatidylglycerophosphatase b; Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are [...] | 0.621 |
| yciM | pyrF | b1280 | b1281 | Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) | 0.627 |
| yciM | yciS | b1280 | b1279 | Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane | DUF1049 family inner membrane protein, function unknown; Involved in the assembly of lipopolysaccharide (LPS) | 0.987 |
| yciS | gsiA | b1279 | b0829 | DUF1049 family inner membrane protein, function unknown; Involved in the assembly of lipopolysaccharide (LPS) | Glutathione abc transporter atp binding subunit gsia; Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system | 0.600 |
| yciS | hns | b1279 | b1237 | DUF1049 family inner membrane protein, function unknown; Involved in the assembly of lipopolysaccharide (LPS) | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | 0.696 |
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