STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
puuPPutrescine importer PuuP; Involved in the uptake of putrescine; Belongs to the amino acid-polyamine-organocation (APC) superfamily (461 aa)    
Predicted Functional Partners:
puuR
HTH-type transcriptional regulator PuuR; Represses puuA, puuD and puuP
 
  
 0.892
puuD
Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD; Involved in the breakdown of putrescine via hydrolysis of the gamma-glutamyl linkage of gamma-glutamyl-gamma- aminobutyrate
 
  
 0.798
puuA
Gamma-glutamylputrescine synthetase PuuA; Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine. It is able to use several diamines, spermidine and spermine. Absolutely essential to utilize putrescine as both nitrogen and carbon sources and to decrease the toxicity of putrescine, which can lead to inhibition of cell growth and protein synthesis; Belongs to the glutamine synthetase family
 
  
 0.773
potE
Putrescine transporter PotE; Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity
      
 0.751
patD
Gamma-aminobutyraldehyde dehydrogenase; Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4- aminobutanoate (GABA). Can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency
      
 0.740
ydcV
Inner membrane ABC transporter permease protein YdcV; Probably part of the binding-protein-dependent transport system YdcSTUV; probably responsible for the translocation of the substrate across the membrane
    
 
 0.620
potC
Spermidine/putrescine transport system permease protein PotC; Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine
    
 
 0.611
potH
Putrescine transport system permease protein PotH; Required for the activity of the bacterial periplasmic transport system of putrescine
      
 0.596
potF
Putrescine-binding periplasmic protein; Required for the activity of the bacterial periplasmic transport system of putrescine. Polyamine binding protein
      
 0.595
speF
Inducible ornithine decarboxylase; Protein involved in polyamine biosynthetic process; Belongs to the Orn/Lys/Arg decarboxylase class-I family
    
 
 0.581
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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