STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ynaIMechanosensitive channel protein, very small conductance; Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Belongs to the MscS (TC 1.A.23) family. (343 aa)    
Predicted Functional Partners:
ybiO
Mechanosensitive channel protein, intermediate conductance; Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Belongs to the MscS (TC 1.A.23) family.
      
 0.964
mscL
Mechanosensitive channel protein, high conductance; Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Forms a nonselective ion channel with a conductance of about 4 nanosiemens. Participates in the regulation of osmotic pressure changes within the cell. Opens at a pressure just below that which would cause cell disruption and death. The force required to trigger channel opening depends on the membrane lipids composition.
     
 0.909
insH1-4
IS5 transposase and trans-activator.
     
 0.729
ynaJ
DUF2534 family putative inner membrane protein.
     
 0.652
mscS
Mechanosensitive channel protein, small conductance; Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activ [...]
  
   
0.523
ybdG
Mechanosensitive channel protein, miniconductance; Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks.
   
  
0.466
mscM
Mechanosensitive channel protein, miniconductance; Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Gates spontaneously in response to increased membrane tension.
  
  
0.430
yrbL
Mg(2+)-starvation-stimulated protein.
  
     0.413
mscK
Mechanosensitive channel protein, intermediate conductance, K+ regulated; Mechanosensitive channel that opens in response to membrane tension and specific ionic conditions. Requires high concentrations of external K(+), NH(4)(+), Rb(+) or Cs(+) to gate. May participate in the regulation of osmotic pressure changes within the cell, although it does not appear to have a major role in osmolarity regulation. Forms an ion channel of 1.0 nanosiemens conductance. The channel can remain active for between 30 seconds and over 3 minutes; it does not desensitize upon extended pressure. Its activi [...]
  
  
0.412
yadS
UPF0126 family inner membrane protein.
   
   0.411
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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