node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
feaB | feaR | b1385 | b1384 | Phenylacetaldehyde dehydrogenase; Acts almost equally well on phenylacetaldehyde, 4- hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde. | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | 0.959 |
feaB | tynA | b1385 | b1386 | Phenylacetaldehyde dehydrogenase; Acts almost equally well on phenylacetaldehyde, 4- hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde. | Tyramine oxidase, copper-requiring; The enzyme prefers aromatic over aliphatic amines; Belongs to the copper/topaquinone oxidase family. | 0.992 |
feaR | feaB | b1384 | b1385 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | Phenylacetaldehyde dehydrogenase; Acts almost equally well on phenylacetaldehyde, 4- hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde. | 0.959 |
feaR | glcC | b1384 | b2980 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | Glycolate-inducible glc operon transcriptional repressor; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector. | 0.545 |
feaR | hcaR | b1384 | b2537 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | 0.759 |
feaR | marA | b1384 | b1531 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | 0.460 |
feaR | mhpR | b1384 | b0346 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | Mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway. | 0.476 |
feaR | soxS | b1384 | b4062 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | Superoxide response regulon transcriptional activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. | 0.491 |
feaR | tynA | b1384 | b1386 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | Tyramine oxidase, copper-requiring; The enzyme prefers aromatic over aliphatic amines; Belongs to the copper/topaquinone oxidase family. | 0.929 |
feaR | ycdU | b1384 | b1029 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | Uncharacterized protein YcdU; Pseudogene. | 0.623 |
feaR | yidZ | b1384 | b3711 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | Putative DNA-binding transcriptional regulator; Involved in anaerobic NO protection. | 0.457 |
feaR | yqjI | b1384 | b3071 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | PadR family putative transcriptional regulator; Represses the expression of YqjH which is involved in iron homeostasis under excess nickel conditions. Also represses its own expression. | 0.530 |
glcC | feaR | b2980 | b1384 | Glycolate-inducible glc operon transcriptional repressor; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector. | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | 0.545 |
glcC | hcaR | b2980 | b2537 | Glycolate-inducible glc operon transcriptional repressor; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector. | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | 0.846 |
glcC | mhpR | b2980 | b0346 | Glycolate-inducible glc operon transcriptional repressor; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector. | Mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway. | 0.867 |
hcaR | feaR | b2537 | b1384 | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | 0.759 |
hcaR | glcC | b2537 | b2980 | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | Glycolate-inducible glc operon transcriptional repressor; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector. | 0.846 |
hcaR | mhpR | b2537 | b0346 | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | Mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway. | 0.757 |
marA | feaR | b1531 | b1384 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | 0.460 |
mhpR | feaR | b0346 | b1384 | Mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway. | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | 0.476 |