STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
feaRArac family transcriptional regulator, positive regulator of tyna and feab; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism (301 aa)    
Predicted Functional Partners:
tynA
Tyramine oxidase, copper-requiring; The enzyme prefers aromatic over aliphatic amines
  
 0.977
feaB
Phenylacetaldehyde dehydrogenase; Acts almost equally well on phenylacetaldehyde, 4- hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde
 
  
 0.949
hcaR
Lysr family transcriptional regulator, hca operon transcriptional activator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism
  
  
 0.722
paaX
Transcriptional repressor of phenylacetic acid degradation paa operon, phenylacetyl-coa inducer; Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'-WWTRTGATTCGYGWT-3'. Binding of PaaX is specifically inhibited by phenylacetyl-coenzyme A (PA-CoA)
 
  
 0.683
mhpR
Iclr family transcriptional regulator, mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway
  
  
 0.652
yhjC
Putative dna-binding transcriptional regulator yhjc; Belongs to the LysR transcriptional regulatory family
   
  
 0.610
yaiV
Putative dna-binding transcriptional regulator ipra; Involved in oxidative stress resistance
      
 0.607
rspR
Gntr family transcriptional regulator, rspab operon transcriptional repressor; Repressor of the rspAB operon. Acts by binding directly to the upstream region of rspA
      
 0.605
glcC
Gntr family transcriptional regulator, glc operon transcriptional activator; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity Also negatively regulates the transcription of its own gene . Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector
   
  
 0.602
tdcA
Lysr family transcriptional regulator, tdc operon transcriptional activator; Transcriptional activator for the tdcABCDE operon
   
  
 0.564
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.