STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
hrpAAtp-dependent rna helicase hrpa; Not yet known (1300 aa)    
Predicted Functional Partners:
Atp-dependent rna helicase rhlb; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA
Required for translation of most natural mRNAs except for leaderless mRNA Binds mRNA upstream of the Shine- Dalgarno (SD) sequence and helps it bind to the 30S ribosomal subunit; acts as an RNA chaperone to unfold structured mRNA on the ribosome but is not essential for mRNAs with strong SDs and little 5'-UTR structure, thus it may help fine-tune which mRNAs that are translated . Unwinds dsRNA by binding to transiently formed ssRNA regions; binds about 10 nucleotides . Has a preference for polypyrimidine tracts . Negatively autoregulates its own translation . In case of infection by ba [...]
Atp-dependent rna helicase rhle; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. May play a role in the interconversion of ribosomal RNA-folding intermediates that are further processed by DeaD or SrmB during ribosome maturation
Atp-dependent rna helicase srmb; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity. Acts before DeaD
Ribonuclease d; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Trna m(7)g46 methyltransferase, sam-dependent; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
Mannitol-1-/sugar-/sorbitol-6-phosphatase; Sugar-phosphate phosphohydrolase that appears to contribute to butanol tolerance . Catalyzes the dephosphorylation of D-mannitol 1-phosphate and D-sorbitol 6-phosphate . Is also able to dephosphorylate other sugar phosphates in vitro including ribose-5-phosphate (Rib5P), 2-deoxyribose-5-phosphate, fructose-1-phosphate (Fru1P), fructose-6-phosphate (Fru6P), and glucose-6-phosphate (Glu6P) . Selectively hydrolyzes beta-D-glucose-1-phosphate (bGlu1P) and has no activity with the alpha form
Rna-binding protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32 . Binds with high specificity to tRNAs . Binds sRNA antitoxin RalA . In vitro, stimulates synthesis of long tails by poly(A) polymerase I . Required for RNA phage Qbeta replication . Seems to play a role in persister cell formation; upon overexpression decreas [...]
Poly(a) polymerase i; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Rho-independent transcription terminators may serve as polyadenylation signals. Seems to be involved in plasmid copy number control
Constitutive cold shock family transcription antitermination protein; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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