node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hokB | mokB | b4428 | b1420 | Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system (Probable). When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration. Expression leads to membrane depolarization; when protein levels are high enough depolarization probably leads to lowered metabolic activity which in turn induces some cells to enter the persistent state in which they transiently survive antibiotic exposure. Its toxic effect is probably neutralized by antisense antitoxin RNA SokB, which is encoded in trans on the opposite DN [...] | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | 0.958 |
hokB | ydcA | b4428 | b1419 | Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system (Probable). When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration. Expression leads to membrane depolarization; when protein levels are high enough depolarization probably leads to lowered metabolic activity which in turn induces some cells to enter the persistent state in which they transiently survive antibiotic exposure. Its toxic effect is probably neutralized by antisense antitoxin RNA SokB, which is encoded in trans on the opposite DN [...] | Putative periplasmic protein. | 0.452 |
mokB | hokB | b1420 | b4428 | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system (Probable). When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration. Expression leads to membrane depolarization; when protein levels are high enough depolarization probably leads to lowered metabolic activity which in turn induces some cells to enter the persistent state in which they transiently survive antibiotic exposure. Its toxic effect is probably neutralized by antisense antitoxin RNA SokB, which is encoded in trans on the opposite DN [...] | 0.958 |
mokB | sufE | b1420 | b1679 | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | Sulfur acceptor protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process. Together with the SufBCD complex, it thereby enhances up to 50-fold, the cysteine desulfurase activity of SufS. Component of [...] | 0.505 |
mokB | trg | b1420 | b1421 | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | Methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor; Mediates taxis to the sugars ribose and galactose via an interaction with the periplasmic ribose- or galactose-binding proteins. | 0.590 |
mokB | ybaM | b1420 | b0466 | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | DUF2496 family protein. | 0.509 |
mokB | ybhL | b1420 | b0786 | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | Putative acetate transporter; BAX Inhibitor-1 family inner membrane protein. | 0.521 |
mokB | ydbL | b1420 | b1383 | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | DUF1318 family protein. | 0.505 |
mokB | ydcA | b1420 | b1419 | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | Putative periplasmic protein. | 0.599 |
mokB | ydcJ | b1420 | b1423 | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | Putative metalloenzyme; To M.tuberculosis Rv3292. | 0.527 |
mokB | ydfO | b1420 | b1549 | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | Qin prophage; uncharacterized protein; To E.coli YbcV and YcgX. | 0.501 |
mokB | yniB | b1420 | b1726 | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | Putative inner membrane protein. | 0.511 |
sufE | mokB | b1679 | b1420 | Sulfur acceptor protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process. Together with the SufBCD complex, it thereby enhances up to 50-fold, the cysteine desulfurase activity of SufS. Component of [...] | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | 0.505 |
sufE | ybaM | b1679 | b0466 | Sulfur acceptor protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process. Together with the SufBCD complex, it thereby enhances up to 50-fold, the cysteine desulfurase activity of SufS. Component of [...] | DUF2496 family protein. | 0.528 |
sufE | ydbL | b1679 | b1383 | Sulfur acceptor protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process. Together with the SufBCD complex, it thereby enhances up to 50-fold, the cysteine desulfurase activity of SufS. Component of [...] | DUF1318 family protein. | 0.492 |
sufE | ydfO | b1679 | b1549 | Sulfur acceptor protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process. Together with the SufBCD complex, it thereby enhances up to 50-fold, the cysteine desulfurase activity of SufS. Component of [...] | Qin prophage; uncharacterized protein; To E.coli YbcV and YcgX. | 0.459 |
sufE | yniB | b1679 | b1726 | Sulfur acceptor protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process. Together with the SufBCD complex, it thereby enhances up to 50-fold, the cysteine desulfurase activity of SufS. Component of [...] | Putative inner membrane protein. | 0.517 |
trg | mokB | b1421 | b1420 | Methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor; Mediates taxis to the sugars ribose and galactose via an interaction with the periplasmic ribose- or galactose-binding proteins. | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | 0.590 |
ybaM | mokB | b0466 | b1420 | DUF2496 family protein. | Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression. | 0.509 |
ybaM | sufE | b0466 | b1679 | DUF2496 family protein. | Sulfur acceptor protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process. Together with the SufBCD complex, it thereby enhances up to 50-fold, the cysteine desulfurase activity of SufS. Component of [...] | 0.528 |