STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yncDPutative iron outer membrane transporter; Probable receptor, TonB-dependent. (700 aa)    
Predicted Functional Partners:
yncE
ATP-binding protein, periplasmic, function unknown; Putative receptor.
 
  
 0.900
fhuE
Ferric-rhodotorulic acid outer membrane transporter; Required for the uptake of Fe(3+) via coprogen, ferrioxamine B, and rhodotorulic acid.
  
  
 0.749
fepA
Ferrienterobactin outer membrane transporter; This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D.
 
  
0.720
tonB
Membrane spanning protein in TonB-ExbB-ExbD transport complex; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to tran [...]
 
  
 0.658
opgB
OPG periplasmic biosynthetic phosphoglycerol transferases I (membrane-bound) and II (soluble); Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones. Belongs to the OpgB family.
  
     0.628
ybeR
Uncharacterized protein; To E.coli YbeU.
    
 
 0.574
ybeU
DUF1266 family protein; Putative tRNA ligase; To E.coli YbeR.
    
 
 0.574
ynjI
Inner membrane protein.
    
 
 0.574
ypjA
Adhesin-like autotransporter; Putative ATP-binding component of a transport system.
    
 
 0.573
cirA
Colicin IA outer membrane receptor and translocator; Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB.
 
  
0.567
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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